Metformin and the ATM DNA damage response (DDR): Accelerating the onset of stress-induced senescence to boost protection against cancer
By activating the ataxia telangiectasia mutated (ATM)-mediated DNA Damage Response (DDR), the AMPK agonist metformin might sensitize cells against further damage, thus mimicking the precancerous stimulus that induces an intrinsic barrier against carcinogenesis. Herein, we present the new hypothesis...
| Main Authors: | , , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Impact Journals LLC
2011
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249452/ |