IGF-1R/epithelial-to-mesenchymal transition (EMT) crosstalk suppresses the erlotinib-sensitizing effect of EGFR exon 19 deletion mutations

IGF-1R/epithelial-to-mesenchymal transition (EMT) crosstalk suppresses the erlotinib-sensitizing effect of EGFR exon 19 deletion mutations

Using non-small cell lung carcinoma (NSCLC) cells harboring the erlotinib-sensitizing Epidermal Growth Factor Receptor (EGFR) exon 19 mutation delE746-A750, we developed erlotinib-refractory derivatives in which hyperactive Insulin-like Growth Factor-1 Receptor (IGF-1R) signaling associated with enr...

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Bibliographic Details
Main Authors: Vazquez-Martin, Alejandro, Cufí, Sílvia, Oliveras-Ferraros, Cristina, Torres-Garcia, Violeta Zenobia, Corominas-Faja, Bruna, Cuyàs, Elisabet, Bonavia, Rosa, Visa, Joana, Martin-Castillo, Begoña, Barrajón-Catalán, Enrique, Micol, Vicente, Bosch-Barrera, Joaquim, Menendez, Javier A.
Format: Online
Language:English
Published: Nature Publishing Group 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759044/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759044/

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