p21-activated kinase 1: PAK'ed with potential

The p21-activated kinases (PAKs) are central players in growth factor signaling networks and morphogenetic processes that control proliferation, cell polarity, invasion and actin cytoskeleton organization. This raises the possibility that interfering with PAK activity may produce significant anti-tu...

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Main Authors:	Ong, Christy C., Jubb, Adrian M., Zhou, Wei, Haverty, Peter M., Harris, Adrian L., Belvin, Marcia, Friedman, Lori S., Koeppen, Hartmut, Hoeflich, Klaus P.
Format:	Online
Language:	English
Published:	Impact Journals LLC 2011
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3248206/

id	pubmed-3248206
recordtype	oai_dc
spelling	pubmed-32482062012-01-18 p21-activated kinase 1: PAK'ed with potential Ong, Christy C. Jubb, Adrian M. Zhou, Wei Haverty, Peter M. Harris, Adrian L. Belvin, Marcia Friedman, Lori S. Koeppen, Hartmut Hoeflich, Klaus P. Research Perspectives The p21-activated kinases (PAKs) are central players in growth factor signaling networks and morphogenetic processes that control proliferation, cell polarity, invasion and actin cytoskeleton organization. This raises the possibility that interfering with PAK activity may produce significant anti-tumor activity. In this perspective, we summarize recent data concerning the contribution of the PAK family member, PAK1, in growth factor signaling and tumorigenesis. We further discuss mechanisms by which inhibition of PAK1 can arrest tumor growth and promote cell apoptosis, and the types of cancers in which PAK1 inhibition may hold promise. Impact Journals LLC 2011-06-07 /pmc/articles/PMC3248206/ /pubmed/21653999 Text en Copyright: © 2011 Ong et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Ong, Christy C. Jubb, Adrian M. Zhou, Wei Haverty, Peter M. Harris, Adrian L. Belvin, Marcia Friedman, Lori S. Koeppen, Hartmut Hoeflich, Klaus P.
spellingShingle	Ong, Christy C. Jubb, Adrian M. Zhou, Wei Haverty, Peter M. Harris, Adrian L. Belvin, Marcia Friedman, Lori S. Koeppen, Hartmut Hoeflich, Klaus P. p21-activated kinase 1: PAK'ed with potential
author_facet	Ong, Christy C. Jubb, Adrian M. Zhou, Wei Haverty, Peter M. Harris, Adrian L. Belvin, Marcia Friedman, Lori S. Koeppen, Hartmut Hoeflich, Klaus P.
author_sort	Ong, Christy C.
title	p21-activated kinase 1: PAK'ed with potential
title_short	p21-activated kinase 1: PAK'ed with potential
title_full	p21-activated kinase 1: PAK'ed with potential
title_fullStr	p21-activated kinase 1: PAK'ed with potential
title_full_unstemmed	p21-activated kinase 1: PAK'ed with potential
title_sort	p21-activated kinase 1: pak'ed with potential
description	The p21-activated kinases (PAKs) are central players in growth factor signaling networks and morphogenetic processes that control proliferation, cell polarity, invasion and actin cytoskeleton organization. This raises the possibility that interfering with PAK activity may produce significant anti-tumor activity. In this perspective, we summarize recent data concerning the contribution of the PAK family member, PAK1, in growth factor signaling and tumorigenesis. We further discuss mechanisms by which inhibition of PAK1 can arrest tumor growth and promote cell apoptosis, and the types of cancers in which PAK1 inhibition may hold promise.
publisher	Impact Journals LLC
publishDate	2011
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3248206/
_version_	1611497305923387392

p21-activated kinase 1: PAK'ed with potential

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