Role of dual PI3/Akt and mTOR inhibition in Waldenstrom's Macroglobulinemia
Tumorigenesis occurs due to synergistic interactions from a complex of signal transduction processes, including multiple onco-proteins and tumor suppressors such as Ras, Myc, PI3K/Akt/mTOR, Her-2/Neu, p53 and PTEN. Specifically, the PI3K/Akt and mTOR pathways have been shown to play a pivotal role o...
| Main Authors: | , , |
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| Format: | Online |
| Language: | English |
| Published: |
Impact Journals LLC
2010
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3248138/ |