Competition for FcRn-mediated transport gives rise to short half-life of human IgG3 and offers therapeutic potential

Competition for FcRn-mediated transport gives rise to short half-life of human IgG3 and offers therapeutic potential

Human IgG3 displays the strongest effector functions of all IgG subclasses but has a short half-life for unresolved reasons. Here we show that IgG3 binds to IgG-salvage receptor (FcRn), but that FcRn-mediated transport and rescue of IgG3 is inhibited in the presence of IgG1 due to intracellular comp...

Full description

Bibliographic Details
Main Authors: Stapleton, Nigel M., Andersen, Jan Terje, Stemerding, Annette M., Bjarnarson, Stefania P., Verheul, Ruurd C., Gerritsen, Jacoline, Zhao, Yixian, Kleijer, Marion, Sandlie, Inger, de Haas, Masja, Jonsdottir, Ingileif, van der Schoot, C. Ellen, Vidarsson, Gestur
Format: Online
Language:English
Published: Nature Publishing Group 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3247843/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3247843/

Similar Items