Pharmacokinetic Models for FcRn-Mediated IgG Disposition
The objectives were to review available PK models for saturable FcRn-mediated IgG disposition, and to explore an alternative semimechanistic model. Most available empirical and mechanistic PK models assumed equal IgG concentrations in plasma and endosome in addition to other model-specific assumptio...
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Format: | Online |
Language: | English |
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Hindawi Publishing Corporation
2012
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Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3361741/ |