Constitutive MAP Kinase Activation in Hematopoietic Stem Cells Induces a Myeloproliferative Disorder
Myelodysplastic syndromes/myeloproliferative neoplasms (MDS/MPNs) are a group of myeloid neoplasms in which abnormal activation of the Ras signaling pathway is commonly observed. The PI3K/Akt pathway is a known target of Ras; however, activation of the PI3K/Akt pathway has been shown to lead to neop...
| Main Authors: | , , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
Public Library of Science
2011
|
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3229546/ |