Genome-wide association study identifies susceptibility loci for Dengue shock syndrome at MICB and PLCE1

Genome-wide association study identifies susceptibility loci for Dengue shock syndrome at MICB and PLCE1

Hypovolemic shock (Dengue shock syndrome (DSS)), is the commonest life-threatening complication of dengue. We conducted a genome-wide association study of 2,008 pediatric cases treated for DSS and 2,018 controls from Vietnam. Replication of the most significantly associated markers was carried out i...

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Bibliographic Details
Main Authors: Khor, Chiea Chuen, Bich, Chau Tran Nguyen, Pang, Junxiong, Davila, Sonia, Long, Hoang Truong, Ong, Rick T.H., Dunstan, Sarah J., Wills, Bridget, Farrar, Jeremy, Van Tram, Ta, Gan, Tran Thi, Binh, Nguyen Thi Nguyet, Tri, Le Trung, Lien, Le Bich, Tuan, Nguyen Minh, Tham, Nguyen Thi Hong, Lanh, Mai Ngoc, Nguyet, Nguyen Minh, Hieu, Nguyen Trong, Van Vinh Chau, Nguyen, Thuy, Tran Thi, Tan, Dennis E.K., Sakuntabhai, Anavaj, Teo, Yik-Ying, Hibberd, Martin L, Simmons, Cameron P.
Format: Online
Language:English
Published: 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3223402/
Description
Summary:Hypovolemic shock (Dengue shock syndrome (DSS)), is the commonest life-threatening complication of dengue. We conducted a genome-wide association study of 2,008 pediatric cases treated for DSS and 2,018 controls from Vietnam. Replication of the most significantly associated markers was carried out in an independent Vietnamese follow-up sample of 1,737 cases and 2,934 controls. Polymorphisms within two genes showed genome-wide significant association with DSS (Pmeta = 4.41 × 10−11, per-allele odds ratio (OR) = 1.34 for MICB rs3132468 located within the broad MHC region and Pmeta = 3.08 × 10−10, per-allele OR = 0.80 for PLCE1 rs3765524). Our data implicates MICB is an important determinant in early immune control of dengue virus infection and PLCE1 a factor in vascular endothelial dysfunction and circulatory hypovolemia.

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