Age-related Purkinje cell death is steroid dependent: RORα haplo-insufficiency impairs plasma and cerebellar steroids and Purkinje cell survival
A major problem of ageing is progressive impairment of neuronal function and ultimately cell death. Since sex steroids are neuroprotective, their decrease with age may underlie age-related neuronal degeneration. To test this, we examined Purkinje cell numbers, plasma sex steroids and cerebellar neur...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Springer Netherlands
2011
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3220403/ |