Age-related Purkinje cell death is steroid dependent: RORα haplo-insufficiency impairs plasma and cerebellar steroids and Purkinje cell survival

Age-related Purkinje cell death is steroid dependent: RORα haplo-insufficiency impairs plasma and cerebellar steroids and Purkinje cell survival

A major problem of ageing is progressive impairment of neuronal function and ultimately cell death. Since sex steroids are neuroprotective, their decrease with age may underlie age-related neuronal degeneration. To test this, we examined Purkinje cell numbers, plasma sex steroids and cerebellar neur...

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Bibliographic Details
Main Authors: Janmaat, Sonja, Akwa, Yvette, Doulazmi, Mohamed, Bakouche, Joëlle, Gautheron, Vanessa, Liere, Philippe, Eychenne, Bernard, Pianos, Antoine, Luiten, Paul, Groothuis, Ton, Baulieu, Etienne-Emile, Mariani, Jean, Sherrard, Rachel M., Frédéric, Florence
Format: Online
Language:English
Published: Springer Netherlands 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3220403/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3220403/

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