Ghrelin and Its Analogues, BIM-28131 and BIM-28125, Improve Body Weight and Regulate the Expression of MuRF-1 and MAFbx in a Rat Heart Failure Model

Ghrelin and Its Analogues, BIM-28131 and BIM-28125, Improve Body Weight and Regulate the Expression of MuRF-1 and MAFbx in a Rat Heart Failure Model

Cardiac cachexia is a serious complication of chronic heart failure with a prevalence of 10–16% and poor prognosis. There are no current therapy options for cardiac cachexia. Ghrelin is the natural ligand for the GHS-1a-receptor and a potential target for conditions associated with cachexia. Ghrelin...

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Bibliographic Details
Main Authors: Palus, Sandra, Schur, Robert, Akashi, Yoshihiro J., Bockmeyer, Barbara, Datta, Rakesh, Halem, Heather, Dong, Jesse, Culler, Michael D., Adams, Volker, Anker, Stefan D., Springer, Jochen
Format: Online
Language:English
Published: Public Library of Science 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3216926/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3216926/

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