PP2A-B56α Controls Oncogene-Induced Senescence in Normal and Tumor Human Melanocytic Cells

PP2A-B56α Controls Oncogene-Induced Senescence in Normal and Tumor Human Melanocytic Cells

Oncoprotein C-MYC is overexpressed in human metastatic melanomas and melanoma-derived cells where it is required for suppression of oncogene-induced senescence (OIS). The genetic events that maintain high levels of C-MYC in melanoma cells and their role in OIS are unknown. Here, we report that C-MYC...

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Bibliographic Details
Main Authors: Mannava, Sudha, Omilian, Angela R., Wawrzyniak, Joseph A., Fink, Emily E., Zhuang, Dazhong, Miecznikowski, Jeffrey C., Marshall, James R., Soengas, Maria S., Sears, Rosalie C., Morrison, Carl D., Nikiforov, Mikhail A.
Format: Online
Language:English
Published: 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3213274/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3213274/

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