In vitro evidence for senescent multinucleated melanocytes as a source for tumor-initiating cells

In vitro evidence for senescent multinucleated melanocytes as a source for tumor-initiating cells

Oncogenic signaling in melanocytes results in oncogene-induced senescence (OIS), a stable cell-cycle arrest frequently characterized by a bi- or multinuclear phenotype that is considered as a barrier to cancer progression. However, the long-sustained conviction that senescence is a truly irreversibl...

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Bibliographic Details
Main Authors: Leikam, C, Hufnagel, A L, Otto, C, Murphy, D J, Mühling, B, Kneitz, S, Nanda, I, Schmid, M, Wagner, T U, Haferkamp, S, Bröcker, E-B, Schartl, M, Meierjohann, S
Format: Online
Language:English
Published: Nature Publishing Group 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4650540/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4650540/

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