Halofuginone Has Anti-Proliferative Effects in Acute Promyelocytic Leukemia by Modulating the Transforming Growth Factor Beta Signaling Pathway

Halofuginone Has Anti-Proliferative Effects in Acute Promyelocytic Leukemia by Modulating the Transforming Growth Factor Beta Signaling Pathway

Promyelocytic leukemia-retinoic acid receptor alpha (PML-RARα) expression in acute promyelocytic leukemia (APL) impairs transforming growth factor beta (TGFβ) signaling, leading to cell growth advantage. Halofuginone (HF), a low-molecular-weight alkaloid that modulates TGFβ signaling, was used to tr...

Full description

Bibliographic Details
Main Authors: de Figueiredo-Pontes, Lorena L., Assis, Patricia A., Santana-Lemos, Bárbara A. A., Jácomo, Rafael H., Lima, Ana Sílvia G., Garcia, Aglair B., Thomé, Carolina H., Araújo, Amélia G., Panepucci, Rodrigo A., Zago, Marco A., Nagler, Arnon, Falcão, Roberto P., Rego, Eduardo M.
Format: Online
Language:English
Published: Public Library of Science 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203897/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203897/

Similar Items