Calcium signaling around Mitochondria Associated Membranes (MAMs)

Calcium (Ca2+) homeostasis is fundamental for cell metabolism, proliferation, differentiation, and cell death. Elevation in intracellular Ca2+ concentration is dependent either on Ca2+ influx from the extracellular space through the plasma membrane, or on Ca2+ release from intracellular Ca2+ stores,...

Full description

Bibliographic Details
Main Authors: Patergnani, Simone, Suski, Jan M, Agnoletto, Chiara, Bononi, Angela, Bonora, Massimo, De Marchi, Elena, Giorgi, Carlotta, Marchi, Saverio, Missiroli, Sonia, Poletti, Federica, Rimessi, Alessandro, Duszynski, Jerzy, Wieckowski, Mariusz R, Pinton, Paolo
Format: Online
Language:English
Published: BioMed Central 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198985/
id pubmed-3198985
recordtype oai_dc
spelling pubmed-31989852011-10-23 Calcium signaling around Mitochondria Associated Membranes (MAMs) Patergnani, Simone Suski, Jan M Agnoletto, Chiara Bononi, Angela Bonora, Massimo De Marchi, Elena Giorgi, Carlotta Marchi, Saverio Missiroli, Sonia Poletti, Federica Rimessi, Alessandro Duszynski, Jerzy Wieckowski, Mariusz R Pinton, Paolo Review Calcium (Ca2+) homeostasis is fundamental for cell metabolism, proliferation, differentiation, and cell death. Elevation in intracellular Ca2+ concentration is dependent either on Ca2+ influx from the extracellular space through the plasma membrane, or on Ca2+ release from intracellular Ca2+ stores, such as the endoplasmic/sarcoplasmic reticulum (ER/SR). Mitochondria are also major components of calcium signalling, capable of modulating both the amplitude and the spatio-temporal patterns of Ca2+ signals. Recent studies revealed zones of close contact between the ER and mitochondria called MAMs (Mitochondria Associated Membranes) crucial for a correct communication between the two organelles, including the selective transmission of physiological and pathological Ca2+ signals from the ER to mitochondria. In this review, we summarize the most up-to-date findings on the modulation of intracellular Ca2+ release and Ca2+ uptake mechanisms. We also explore the tight interplay between ER- and mitochondria-mediated Ca2+ signalling, covering the structural and molecular properties of the zones of close contact between these two networks. BioMed Central 2011-09-22 /pmc/articles/PMC3198985/ /pubmed/21939514 http://dx.doi.org/10.1186/1478-811X-9-19 Text en Copyright ©2011 Patergnani et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Patergnani, Simone
Suski, Jan M
Agnoletto, Chiara
Bononi, Angela
Bonora, Massimo
De Marchi, Elena
Giorgi, Carlotta
Marchi, Saverio
Missiroli, Sonia
Poletti, Federica
Rimessi, Alessandro
Duszynski, Jerzy
Wieckowski, Mariusz R
Pinton, Paolo
spellingShingle Patergnani, Simone
Suski, Jan M
Agnoletto, Chiara
Bononi, Angela
Bonora, Massimo
De Marchi, Elena
Giorgi, Carlotta
Marchi, Saverio
Missiroli, Sonia
Poletti, Federica
Rimessi, Alessandro
Duszynski, Jerzy
Wieckowski, Mariusz R
Pinton, Paolo
Calcium signaling around Mitochondria Associated Membranes (MAMs)
author_facet Patergnani, Simone
Suski, Jan M
Agnoletto, Chiara
Bononi, Angela
Bonora, Massimo
De Marchi, Elena
Giorgi, Carlotta
Marchi, Saverio
Missiroli, Sonia
Poletti, Federica
Rimessi, Alessandro
Duszynski, Jerzy
Wieckowski, Mariusz R
Pinton, Paolo
author_sort Patergnani, Simone
title Calcium signaling around Mitochondria Associated Membranes (MAMs)
title_short Calcium signaling around Mitochondria Associated Membranes (MAMs)
title_full Calcium signaling around Mitochondria Associated Membranes (MAMs)
title_fullStr Calcium signaling around Mitochondria Associated Membranes (MAMs)
title_full_unstemmed Calcium signaling around Mitochondria Associated Membranes (MAMs)
title_sort calcium signaling around mitochondria associated membranes (mams)
description Calcium (Ca2+) homeostasis is fundamental for cell metabolism, proliferation, differentiation, and cell death. Elevation in intracellular Ca2+ concentration is dependent either on Ca2+ influx from the extracellular space through the plasma membrane, or on Ca2+ release from intracellular Ca2+ stores, such as the endoplasmic/sarcoplasmic reticulum (ER/SR). Mitochondria are also major components of calcium signalling, capable of modulating both the amplitude and the spatio-temporal patterns of Ca2+ signals. Recent studies revealed zones of close contact between the ER and mitochondria called MAMs (Mitochondria Associated Membranes) crucial for a correct communication between the two organelles, including the selective transmission of physiological and pathological Ca2+ signals from the ER to mitochondria. In this review, we summarize the most up-to-date findings on the modulation of intracellular Ca2+ release and Ca2+ uptake mechanisms. We also explore the tight interplay between ER- and mitochondria-mediated Ca2+ signalling, covering the structural and molecular properties of the zones of close contact between these two networks.
publisher BioMed Central
publishDate 2011
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198985/
_version_ 1611482678848126976