Calcium signaling around Mitochondria Associated Membranes (MAMs)
Calcium (Ca2+) homeostasis is fundamental for cell metabolism, proliferation, differentiation, and cell death. Elevation in intracellular Ca2+ concentration is dependent either on Ca2+ influx from the extracellular space through the plasma membrane, or on Ca2+ release from intracellular Ca2+ stores,...
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pubmed-31989852011-10-23 Calcium signaling around Mitochondria Associated Membranes (MAMs) Patergnani, Simone Suski, Jan M Agnoletto, Chiara Bononi, Angela Bonora, Massimo De Marchi, Elena Giorgi, Carlotta Marchi, Saverio Missiroli, Sonia Poletti, Federica Rimessi, Alessandro Duszynski, Jerzy Wieckowski, Mariusz R Pinton, Paolo Review Calcium (Ca2+) homeostasis is fundamental for cell metabolism, proliferation, differentiation, and cell death. Elevation in intracellular Ca2+ concentration is dependent either on Ca2+ influx from the extracellular space through the plasma membrane, or on Ca2+ release from intracellular Ca2+ stores, such as the endoplasmic/sarcoplasmic reticulum (ER/SR). Mitochondria are also major components of calcium signalling, capable of modulating both the amplitude and the spatio-temporal patterns of Ca2+ signals. Recent studies revealed zones of close contact between the ER and mitochondria called MAMs (Mitochondria Associated Membranes) crucial for a correct communication between the two organelles, including the selective transmission of physiological and pathological Ca2+ signals from the ER to mitochondria. In this review, we summarize the most up-to-date findings on the modulation of intracellular Ca2+ release and Ca2+ uptake mechanisms. We also explore the tight interplay between ER- and mitochondria-mediated Ca2+ signalling, covering the structural and molecular properties of the zones of close contact between these two networks. BioMed Central 2011-09-22 /pmc/articles/PMC3198985/ /pubmed/21939514 http://dx.doi.org/10.1186/1478-811X-9-19 Text en Copyright ©2011 Patergnani et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
repository_type |
Open Access Journal |
institution_category |
Foreign Institution |
institution |
US National Center for Biotechnology Information |
building |
NCBI PubMed |
collection |
Online Access |
language |
English |
format |
Online |
author |
Patergnani, Simone Suski, Jan M Agnoletto, Chiara Bononi, Angela Bonora, Massimo De Marchi, Elena Giorgi, Carlotta Marchi, Saverio Missiroli, Sonia Poletti, Federica Rimessi, Alessandro Duszynski, Jerzy Wieckowski, Mariusz R Pinton, Paolo |
spellingShingle |
Patergnani, Simone Suski, Jan M Agnoletto, Chiara Bononi, Angela Bonora, Massimo De Marchi, Elena Giorgi, Carlotta Marchi, Saverio Missiroli, Sonia Poletti, Federica Rimessi, Alessandro Duszynski, Jerzy Wieckowski, Mariusz R Pinton, Paolo Calcium signaling around Mitochondria Associated Membranes (MAMs) |
author_facet |
Patergnani, Simone Suski, Jan M Agnoletto, Chiara Bononi, Angela Bonora, Massimo De Marchi, Elena Giorgi, Carlotta Marchi, Saverio Missiroli, Sonia Poletti, Federica Rimessi, Alessandro Duszynski, Jerzy Wieckowski, Mariusz R Pinton, Paolo |
author_sort |
Patergnani, Simone |
title |
Calcium signaling around Mitochondria Associated Membranes (MAMs) |
title_short |
Calcium signaling around Mitochondria Associated Membranes (MAMs) |
title_full |
Calcium signaling around Mitochondria Associated Membranes (MAMs) |
title_fullStr |
Calcium signaling around Mitochondria Associated Membranes (MAMs) |
title_full_unstemmed |
Calcium signaling around Mitochondria Associated Membranes (MAMs) |
title_sort |
calcium signaling around mitochondria associated membranes (mams) |
description |
Calcium (Ca2+) homeostasis is fundamental for cell metabolism, proliferation, differentiation, and cell death. Elevation in intracellular Ca2+ concentration is dependent either on Ca2+ influx from the extracellular space through the plasma membrane, or on Ca2+ release from intracellular Ca2+ stores, such as the endoplasmic/sarcoplasmic reticulum (ER/SR). Mitochondria are also major components of calcium signalling, capable of modulating both the amplitude and the spatio-temporal patterns of Ca2+ signals. Recent studies revealed zones of close contact between the ER and mitochondria called MAMs (Mitochondria Associated Membranes) crucial for a correct communication between the two organelles, including the selective transmission of physiological and pathological Ca2+ signals from the ER to mitochondria. In this review, we summarize the most up-to-date findings on the modulation of intracellular Ca2+ release and Ca2+ uptake mechanisms. We also explore the tight interplay between ER- and mitochondria-mediated Ca2+ signalling, covering the structural and molecular properties of the zones of close contact between these two networks. |
publisher |
BioMed Central |
publishDate |
2011 |
url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198985/ |
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1611482678848126976 |