Quantitative Mass Spectrometry Reveals Dynamics of Factor-inhibiting Hypoxia-inducible Factor-catalyzed Hydroxylation*

Quantitative Mass Spectrometry Reveals Dynamics of Factor-inhibiting Hypoxia-inducible Factor-catalyzed Hydroxylation*

The asparaginyl hydroxylase, factor-inhibiting hypoxia-inducible factor (HIF), is central to the oxygen-sensing pathway that controls the activity of HIF. Factor-inhibiting HIF (FIH) also catalyzes the hydroxylation of a large set of proteins that share a structural motif termed the ankyrin repeat d...

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Bibliographic Details
Main Authors: Singleton, Rachelle S., Trudgian, David C., Fischer, Roman, Kessler, Benedikt M., Ratcliffe, Peter J., Cockman, Matthew E.
Format: Online
Language:English
Published: American Society for Biochemistry and Molecular Biology 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3190818/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3190818/

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