Structural Analysis of Human FANCL, the E3 Ligase in the Fanconi Anemia Pathway*

Structural Analysis of Human FANCL, the E3 Ligase in the Fanconi Anemia Pathway*

The Fanconi anemia (FA) pathway is essential for the repair of DNA interstrand cross-links. At the heart of this pathway is the monoubiquitination of the FANCI-FANCD2 (ID) complex by the multiprotein “core complex” containing the E3 ubiquitin ligase FANCL. Vertebrate organisms have the eight-protein...

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Bibliographic Details
Main Authors: Hodson, Charlotte, Cole, Ambrose R., Lewis, Laurence P. C., Miles, Jennifer A., Purkiss, Andrew, Walden, Helen
Format: Online
Language:English
Published: American Society for Biochemistry and Molecular Biology 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3173227/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3173227/

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