Influence of PB2 host-range determinants on the intranuclear mobility of the influenza A virus polymerase
Avian influenza A viruses often do not propagate efficiently in mammalian cells. The viral polymerase protein PB2 is important for this host restriction, with amino-acid polymorphisms at residue 627 and other positions acting as ‘signatures’ of avian- or human-adapted viruses. Restriction is hypothe...
| Main Authors: | , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Society for General Microbiology
2011
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3167894/ |