Calcium signals and calpain-dependent necrosis are essential for release of coxsackievirus B from polarized intestinal epithelial cells
In contrast to nonpolarized cells, coxsackievirus B (CVB)–infected polarized intestinal Caco-2 cells undergo necrotic cell death triggered by inositol 1,4,5-trisphosphate receptor–dependent calcium release. This CVB-induced necrosis depends on Ca2+-activated calpain-2, which is required for disrupti...
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Bibliographic Details
| Main Authors: |
Bozym, Rebecca A.,
Patel, Kunal,
White, Carl,
Cheung, King-Ho,
Bergelson, Jeffrey M.,
Morosky, Stefanie A.,
Coyne, Carolyn B. |
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| Format: | Online
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| Language: | English |
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| Published: |
The American Society for Cell Biology
2011
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164450/
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