Calcium signals and calpain-dependent necrosis are essential for release of coxsackievirus B from polarized intestinal epithelial cells

Calcium signals and calpain-dependent necrosis are essential for release of coxsackievirus B from polarized intestinal epithelial cells

In contrast to nonpolarized cells, coxsackievirus B (CVB)–infected polarized intestinal Caco-2 cells undergo necrotic cell death triggered by inositol 1,4,5-trisphosphate receptor–dependent calcium release. This CVB-induced necrosis depends on Ca2+-activated calpain-2, which is required for disrupti...

Full description

Bibliographic Details
Main Authors: Bozym, Rebecca A., Patel, Kunal, White, Carl, Cheung, King-Ho, Bergelson, Jeffrey M., Morosky, Stefanie A., Coyne, Carolyn B.
Format: Online
Language:English
Published: The American Society for Cell Biology 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164450/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164450/

Similar Items