Predisposition to Cancer Caused by Genetic and Functional Defects of Mammalian Atad5

Predisposition to Cancer Caused by Genetic and Functional Defects of Mammalian Atad5

ATAD5, the human ortholog of yeast Elg1, plays a role in PCNA deubiquitination. Since PCNA modification is important to regulate DNA damage bypass, ATAD5 may be important for suppression of genomic instability in mammals in vivo. To test this hypothesis, we generated heterozygous (Atad5+/m) mice tha...

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Main Authors: Bell, Daphne W., Sikdar, Nilabja, Lee, Kyoo-young, Price, Jessica C., Chatterjee, Raghunath, Park, Hee-Dong, Fox, Jennifer, Ishiai, Masamichi, Rudd, Meghan L., Pollock, Lana M., Fogoros, Sarah K., Mohamed, Hassan, Hanigan, Christin L., Zhang, Suiyuan, Cruz, Pedro, Renaud, Gabriel, Hansen, Nancy F., Cherukuri, Praveen F., Borate, Bhavesh, McManus, Kirk J., Stoepel, Jan, Sipahimalani, Payal, Godwin, Andrew K., Sgroi, Dennis C., Merino, Maria J., Elliot, Gene, Elkahloun, Abdel, Vinson, Charles, Takata, Minoru, Mullikin, James C., Wolfsberg, Tyra G., Hieter, Philip, Lim, Dae-Sik, Myung, Kyungjae
Format: Online
Language:English
Published: Public Library of Science 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3161924/

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