Brain-Derived Neurotrophic Factor in Patients with Huntington's Disease
Reduced Brain-Derived Neurotrophic Factor (BDNF) levels have been described in a number of patho-physiological conditions, most notably, in Huntington's disease (HD), a progressive neurodegenerative disorder. Since BDNF is also produced in blood, we have undertaken the measurement of its periph...
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| Format: | Online |
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Public Library of Science
2011
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3155522/ |
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pubmed-31555222011-08-19 Brain-Derived Neurotrophic Factor in Patients with Huntington's Disease Zuccato, Chiara Marullo, Manuela Vitali, Barbara Tarditi, Alessia Mariotti, Caterina Valenza, Marta Lahiri, Nayana Wild, Edward J. Sassone, Jenny Ciammola, Andrea Bachoud-Lèvi, Anne Catherine Tabrizi, Sarah J. Di Donato, Stefano Cattaneo, Elena Research Article Reduced Brain-Derived Neurotrophic Factor (BDNF) levels have been described in a number of patho-physiological conditions, most notably, in Huntington's disease (HD), a progressive neurodegenerative disorder. Since BDNF is also produced in blood, we have undertaken the measurement of its peripheral levels in the attempt to identify a possible link with HD prognosis and/or its progression. Here we evaluated BDNF level in 398 blood samples including 138 controls, 56 preHD, and 204 HD subjects. We found that BDNF protein levels were not reliably different between groups, whether measured in plasma (52 controls, 26 preHD, 105 HD) or serum (39 controls, 5 preHD, 29 HD). Our experience, and a re-analysis of the literature highlighted that intra-group variability and methodological aspects affect this measurement, especially in serum. We also assessed BDNF mRNA levels in blood samples from 47 controls, 25 preHD, and 70 HD subjects, and found no differences among the groups. We concluded that levels of BDNF in human blood were not informative (mRNA levels or plasma protein level) nor reliable (serum protein levels) as HD biomarkers. We also wish to warn the scientific community in interpreting the significance of changes measured in BDNF protein levels in serum from patients suffering from different conditions. Public Library of Science 2011-08-12 /pmc/articles/PMC3155522/ /pubmed/21857974 http://dx.doi.org/10.1371/journal.pone.0022966 Text en Zuccato et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Zuccato, Chiara Marullo, Manuela Vitali, Barbara Tarditi, Alessia Mariotti, Caterina Valenza, Marta Lahiri, Nayana Wild, Edward J. Sassone, Jenny Ciammola, Andrea Bachoud-Lèvi, Anne Catherine Tabrizi, Sarah J. Di Donato, Stefano Cattaneo, Elena |
| spellingShingle |
Zuccato, Chiara Marullo, Manuela Vitali, Barbara Tarditi, Alessia Mariotti, Caterina Valenza, Marta Lahiri, Nayana Wild, Edward J. Sassone, Jenny Ciammola, Andrea Bachoud-Lèvi, Anne Catherine Tabrizi, Sarah J. Di Donato, Stefano Cattaneo, Elena Brain-Derived Neurotrophic Factor in Patients with Huntington's Disease |
| author_facet |
Zuccato, Chiara Marullo, Manuela Vitali, Barbara Tarditi, Alessia Mariotti, Caterina Valenza, Marta Lahiri, Nayana Wild, Edward J. Sassone, Jenny Ciammola, Andrea Bachoud-Lèvi, Anne Catherine Tabrizi, Sarah J. Di Donato, Stefano Cattaneo, Elena |
| author_sort |
Zuccato, Chiara |
| title |
Brain-Derived Neurotrophic Factor in Patients with Huntington's Disease |
| title_short |
Brain-Derived Neurotrophic Factor in Patients with Huntington's Disease |
| title_full |
Brain-Derived Neurotrophic Factor in Patients with Huntington's Disease |
| title_fullStr |
Brain-Derived Neurotrophic Factor in Patients with Huntington's Disease |
| title_full_unstemmed |
Brain-Derived Neurotrophic Factor in Patients with Huntington's Disease |
| title_sort |
brain-derived neurotrophic factor in patients with huntington's disease |
| description |
Reduced Brain-Derived Neurotrophic Factor (BDNF) levels have been described in a number of patho-physiological conditions, most notably, in Huntington's disease (HD), a progressive neurodegenerative disorder. Since BDNF is also produced in blood, we have undertaken the measurement of its peripheral levels in the attempt to identify a possible link with HD prognosis and/or its progression. Here we evaluated BDNF level in 398 blood samples including 138 controls, 56 preHD, and 204 HD subjects. We found that BDNF protein levels were not reliably different between groups, whether measured in plasma (52 controls, 26 preHD, 105 HD) or serum (39 controls, 5 preHD, 29 HD). Our experience, and a re-analysis of the literature highlighted that intra-group variability and methodological aspects affect this measurement, especially in serum. We also assessed BDNF mRNA levels in blood samples from 47 controls, 25 preHD, and 70 HD subjects, and found no differences among the groups. We concluded that levels of BDNF in human blood were not informative (mRNA levels or plasma protein level) nor reliable (serum protein levels) as HD biomarkers. We also wish to warn the scientific community in interpreting the significance of changes measured in BDNF protein levels in serum from patients suffering from different conditions. |
| publisher |
Public Library of Science |
| publishDate |
2011 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3155522/ |
| _version_ |
1611470764850020352 |