8-Oxo-7,8-dihydroguanine in DNA does not constitute a barrier to transcription, but is converted into transcription-blocking damage by OGG1

8-Oxo-7,8-dihydroguanine in DNA does not constitute a barrier to transcription, but is converted into transcription-blocking damage by OGG1

The common DNA base modification 8-oxo-7,8-dihydroguanine (8-oxo-G) affects the efficiency and fidelity of transcription. We constructed plasmid substrates carrying single 8-oxo-G residues, specifically positioned in the transcribed or the non-transcribed DNA strands, to investigate their effects on...

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Bibliographic Details
Main Authors: Kitsera, Nataliya, Stathis, Dimitrios, Lühnsdorf, Bork, Müller, Heiko, Carell, Thomas, Epe, Bernd, Khobta, Andriy
Format: Online
Language:English
Published: Oxford University Press 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3152326/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3152326/

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