Elevated frequencies of leukemic myeloid and plasmacytoid dendritic cells in acute myeloid leukemia with the FLT3 internal tandem duplication

Elevated frequencies of leukemic myeloid and plasmacytoid dendritic cells in acute myeloid leukemia with the FLT3 internal tandem duplication

Some 30% of acute myeloid leukemia (AML) patients display an internal tandem duplication (ITD) mutation in the FMS-like tyrosine kinase 3 (FLT3) gene. FLT3-ITDs are known to drive hematopoietic stem cells towards FLT3 ligand independent growth, but the effects on dendritic cell (DC) differentiation...

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Bibliographic Details
Main Authors: Rickmann, Mareike, Krauter, Juergen, Stamer, Kathrin, Heuser, Michael, Salguero, Gustavo, Mischak-Weissinger, Eva, Ganser, Arnold, Stripecke, Renata
Format: Online
Language:English
Published: Springer-Verlag 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3150660/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3150660/

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