11β-Hydroxysteroid dehydrogenases and the brain: From zero to hero, a decade of progress
Expression and function of 11β-hydroxysteroid dehydrogenase (11β-HSD) type 1 and 2. 11β-HSD1 is widely expressed throughout the adult CNS and is key to HPA axis function and cognitive decline during ageing. Conversely, the major central effects of 11β-HSD2 are seen in development, as expression of 1...
| Main Authors: | , , |
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| Format: | Online |
| Language: | English |
| Published: |
Academic Press
2011
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3149101/ |
| Summary: | Expression and function of 11β-hydroxysteroid dehydrogenase (11β-HSD) type 1 and 2. 11β-HSD1 is widely expressed throughout the adult CNS and is key to HPA axis function and cognitive decline during ageing. Conversely, the major central effects of 11β-HSD2 are seen in development, as expression of 11β-HSD2 is high in fetal tissues including the neonate brain and placenta. Loss of 11β-HSD2 from the fetus and fetally-derived tissues results in a life-long phenotype of anxiety, consistent with developmental programming. |
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