A simple DNA gate motif for synthesizing large-scale circuits
The prospects of programming molecular systems to perform complex autonomous tasks have motivated research into the design of synthetic biochemical circuits. Of particular interest to us are cell-free nucleic acid systems that exploit non-covalent hybridization and strand displacement reactions to c...
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| Format: | Online |
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The Royal Society
2011
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3140723/ |
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pubmed-3140723 |
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pubmed-31407232011-07-26 A simple DNA gate motif for synthesizing large-scale circuits Qian, Lulu Winfree, Erik Research Articles The prospects of programming molecular systems to perform complex autonomous tasks have motivated research into the design of synthetic biochemical circuits. Of particular interest to us are cell-free nucleic acid systems that exploit non-covalent hybridization and strand displacement reactions to create cascades that implement digital and analogue circuits. To date, circuits involving at most tens of gates have been demonstrated experimentally. Here, we propose a simple DNA gate architecture that appears suitable for practical synthesis of large-scale circuits involving possibly thousands of gates. The Royal Society 2011-09-07 2011-02-04 /pmc/articles/PMC3140723/ /pubmed/21296792 http://dx.doi.org/10.1098/rsif.2010.0729 Text en This journal is © 2011 The Royal Society http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Qian, Lulu Winfree, Erik |
| spellingShingle |
Qian, Lulu Winfree, Erik A simple DNA gate motif for synthesizing large-scale circuits |
| author_facet |
Qian, Lulu Winfree, Erik |
| author_sort |
Qian, Lulu |
| title |
A simple DNA gate motif for synthesizing large-scale circuits |
| title_short |
A simple DNA gate motif for synthesizing large-scale circuits |
| title_full |
A simple DNA gate motif for synthesizing large-scale circuits |
| title_fullStr |
A simple DNA gate motif for synthesizing large-scale circuits |
| title_full_unstemmed |
A simple DNA gate motif for synthesizing large-scale circuits |
| title_sort |
simple dna gate motif for synthesizing large-scale circuits |
| description |
The prospects of programming molecular systems to perform complex autonomous tasks have motivated research into the design of synthetic biochemical circuits. Of particular interest to us are cell-free nucleic acid systems that exploit non-covalent hybridization and strand displacement reactions to create cascades that implement digital and analogue circuits. To date, circuits involving at most tens of gates have been demonstrated experimentally. Here, we propose a simple DNA gate architecture that appears suitable for practical synthesis of large-scale circuits involving possibly thousands of gates. |
| publisher |
The Royal Society |
| publishDate |
2011 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3140723/ |
| _version_ |
1611466616067850240 |