Ictal but Not Interictal Epileptic Discharges Activate Astrocyte Endfeet and Elicit Cerebral Arteriole Responses

Activation of astrocytes by neuronal signals plays a central role in the control of neuronal activity-dependent blood flow changes in the normal brain. The cellular pathways that mediate neurovascular coupling in the epileptic brain remain, however, poorly defined. In a cortical slice model of epile...

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Bibliographic Details
Main Authors: Gómez-Gonzalo, Marta, Losi, Gabriele, Brondi, Marco, Uva, Laura, Sato, Sebastian Sulis, de Curtis, Marco, Ratto, Gian Michele, Carmignoto, Giorgio
Format: Online
Language:English
Published: Frontiers Research Foundation 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3128928/