Malignancy without immortality? Cellular immortalization as a possible late event in melanoma progression

Malignancy without immortality? Cellular immortalization as a possible late event in melanoma progression

Cell senescence is a permanent growth arrest following extended proliferation. Cultured cancer cells including metastatic melanoma cells often appear immortal (proliferate indefinitely), while uncultured benign nevi (moles) show senescence markers. Here, with new explantation methods, we investigate...

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Bibliographic Details
Main Authors: Soo, Julia K, MacKenzie Ross, Alastair D, Kallenberg, David M, Milagre, Carla, Heung Chong, W, Chow, Jade, Hill, Lucy, Hoare, Stacey, Collinson, Rebecca S, Hossain, Mehnaz, Keith, W Nicol, Marais, Richard, Bennett, Dorothy C
Format: Online
Language:English
Published: Blackwell Publishing Ltd 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3123747/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3123747/

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