Pml represses tumour progression through inhibition of mTOR
The promyelocytic leukaemia gene PML is a pleiotropic tumour suppressor. We have recently demonstrated that PML opposes mTOR-HIF1α-VEGF signalling in hypoxia. To determine the relevance of PML-mTOR antagonism in tumourigenesis, we have intercrossed Pml null mice with Tsc2 heterozygous mice, which de...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
WILEY-VCH Verlag
2011
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3123467/ |