Polymorphisms in Stromal Genes and Susceptibility to Serous Epithelial Ovarian Cancer: A Report from the Ovarian Cancer Association Consortium

Polymorphisms in Stromal Genes and Susceptibility to Serous Epithelial Ovarian Cancer: A Report from the Ovarian Cancer Association Consortium

Alterations in stromal tissue components can inhibit or promote epithelial tumorigenesis. Decorin (DCN) and lumican (LUM) show reduced stromal expression in serous epithelial ovarian cancer (sEOC). We hypothesized that common variants in these genes associate with risk. Associations with sEOC among...

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Main Authors: Amankwah, Ernest K., Wang, Qinggang, Schildkraut, Joellen M., Tsai, Ya-Yu, Ramus, Susan J., Fridley, Brooke L., Beesley, Jonathan, Johnatty, Sharon E., Webb, Penelope M., Chenevix-Trench, Georgia, Dale, Laura C., Lambrechts, Diether, Amant, Frederic, Despierre, Evelyn, Vergote, Ignace, Gayther, Simon A., Gentry-Maharaj, Aleksandra, Menon, Usha, Chang-Claude, Jenny, Wang-Gohrke, Shan, Anton-Culver, Hoda, Ziogas, Argyrios, Dörk, Thilo, Dürst, Matthias, Antonenkova, Natalia, Bogdanova, Natalia, Brown, Robert, Flanagan, James M., Kaye, Stanley B., Paul, James, Bützow, Ralf, Nevanlinna, Heli, Campbell, Ian, Eccles, Diana M., Karlan, Beth Y., Gross, Jenny, Walsh, Christine, Pharoah, Paul D. P., Song, Honglin, Krüger Kjær, Susanne, Høgdall, Estrid, Høgdall, Claus, Lundvall, Lene, Nedergaard, Lotte, Kiemeney, Lambertus A. L. M., Massuger, Leon F. A. G., van Altena, Anne M., Vermeulen, Sita H. H. M., Le, Nhu D., Brooks-Wilson, Angela, Cook, Linda S., Phelan, Catherine M., Cunningham, Julie M., Vachon, Celine M., Vierkant, Robert A., Iversen, Edwin S., Berchuck, Andrew, Goode, Ellen L., Sellers, Thomas A., Kelemen, Linda E.
Format: Online
Language:English
Published: Public Library of Science 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3103497/

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