PAPP-A proteolytic activity enhances IGF bioactivity in ascites from women with ovarian carcinoma

PAPP-A proteolytic activity enhances IGF bioactivity in ascites from women with ovarian carcinoma

Pregnancy-associated plasma protein-A (PAPP-A) stimulates insulin-like growth factor (IGF) action through proteolysis of IGF-binding protein (IGFBP)-4. In experimental animals, PAPP-A accelerates ovarian tumor growth by this mechanism. To investigate the effect of PAPP-A in humans, we compared serum...

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Bibliographic Details
Main Authors: Thomsen, Jacob, Hjortebjerg, Rikke, Espelund, Ulrick, Ørtoft, Gitte, Vestergaard, Poul, Magnusson, Nils E., Conover, Cheryl A., Tramm, Trine, Hager, Henrik, Høgdall, Claus, Høgdall, Estrid, Oxvig, Claus, Frystyk, Jan
Format: Online
Language:English
Published: Impact Journals LLC 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741676/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741676/

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