Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study

The prevalence of hypertension in African Americans (AAs) is higher than in other US groups; yet, few have performed genome-wide association studies (GWASs) in AA. Among people of European descent, GWASs have identified genetic variants at 13 loci that are associated with blood pressure. It is unkno...

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Main Authors:	Fox, Ervin R., Young, J. Hunter, Li, Yali, Dreisbach, Albert W., Keating, Brendan J., Musani, Solomon K., Liu, Kiang, Morrison, Alanna C., Ganesh, Santhi, Kutlar, Abdullah, Ramachandran, Vasan S., Polak, Josef F., Fabsitz, Richard R., Dries, Daniel L., Farlow, Deborah N., Redline, Susan, Adeyemo, Adebowale, Hirschorn, Joel N., Sun, Yan V., Wyatt, Sharon B., Penman, Alan D., Palmas, Walter, Rotter, Jerome I., Townsend, Raymond R., Doumatey, Ayo P., Tayo, Bamidele O., Mosley, Thomas H., Lyon, Helen N., Kang, Sun J., Rotimi, Charles N., Cooper, Richard S., Franceschini, Nora, Curb, J. David, Martin, Lisa W., Eaton, Charles B., Kardia, Sharon L.R., Taylor, Herman A., Caulfield, Mark J., Ehret, Georg B., Johnson, Toby, Chakravarti, Aravinda, Zhu, Xiaofeng, Levy, Daniel, Munroe, Patricia B., Rice, Kenneth M., Bochud, Murielle, Johnson, Andrew D., Chasman, Daniel I., Smith, Albert V., Tobin, Martin D., Verwoert, Germaine C., Hwang, Shih-Jen, Pihur, Vasyl, Vollenweider, Peter, O'Reilly, Paul F., Amin, Najaf, Bragg-Gresham, Jennifer L., Teumer, Alexander, Glazer, Nicole L., Launer, Lenore, Zhao, Jing Hua, Aulchenko, Yurii, Heath, Simon, Sõber, Siim, Parsa, Afshin, Luan, Jian'an, Arora, Pankaj, Dehghan, Abbas, Zhang, Feng, Lucas, Gavin, Hicks, Andrew A., Jackson, Anne U., Peden, John F., Tanaka, Toshiko, Wild, Sarah H., Rudan, Igor, Igl, Wilmar, Milaneschi, Yuri, Parker, Alex N., Fava, Cristiano, Chambers, John C., Kumari, Meena, JinGo, Min, van der Harst, Pim, Kao, Wen Hong Linda, Sjögren, Marketa, Vinay, D.G., Alexander, Myriam, Tabara, Yasuharu, Shaw-Hawkins, Sue, Whincup, Peter H., Liu, Yongmei, Shi, Gang, Kuusisto, Johanna, Seielstad, Mark, Sim, Xueling, Nguyen, Khanh-Dung Hoang, Lehtimäki, Terho, Matullo, Giuseppe, Wu, Ying, Gaunt, Tom R., Charlotte Onland-Moret, N., Cooper, Matthew N., Platou, Carl G.P., Org, Elin, Hardy, Rebecca, Dahgam, Santosh, Palmen, Jutta, Vitart, Veronique, Braund, Peter S., Kuznetsova, Tatiana, Uiterwaal, Cuno S.P.M., Campbell, Harry, Ludwig, Barbara, Tomaszewski, Maciej, Tzoulaki, Ioanna, Palmer, Nicholette D., Aspelund, Thor, Garcia, Melissa, Chang, Yen-Pei C., O'Connell, Jeffrey R., Steinle, Nanette I., Grobbee, Diederick E., Arking, Dan E., Hernandez, Dena, Najjar, Samer, McArdle, Wendy L., Hadley, David, Brown, Morris J., Connell, John M., Hingorani, Aroon D., Day, Ian N.M., Lawlor, Debbie A., Beilby, John P., Lawrence, Robert W., Clarke, Robert, Collins, Rory, Hopewell, Jemma C., Ongen, Halit, Bis, Joshua C., Kähönen, Mika, Viikari, Jorma, Adair, Linda S., Lee, Nanette R., Chen, Ming-Huei, Olden, Matthias, Pattaro, Cristian, Hoffman Bolton, Judith A., Köttgen, Anna, Bergmann, Sven, Mooser, Vincent, Chaturvedi, Nish, Frayling, Timothy M., Islam, Muhammad, Jafar, Tazeen H., Erdmann, Jeanette, Kulkarni, Smita R., Bornstein, Stefan R., Grässler, Jürgen, Groop, Leif, Voight, Benjamin F., Kettunen, Johannes, Howard, Philip, Taylor, Andrew, Guarrera, Simonetta, Ricceri, Fulvio, Emilsson, Valur, Plump, Andrew, Barroso, Inês, Khaw, Kay-Tee, Weder, Alan B., Hunt, Steven C., Bergman, Richard N., Collins, Francis S., Bonnycastle, Lori L., Scott, Laura J., Stringham, Heather M., Peltonen, Leena, Perola, Markus, Vartiainen, Erkki, Brand, Stefan-Martin, Staessen, Jan A., Wang, Thomas J., Burton, Paul R., SolerArtigas, Maria, Dong, Yanbin, Snieder, Harold, Wang, Xiaoling, Zhu, Haidong, Lohman, Kurt K., Rudock, Megan E., Heckbert, Susan R., Smith, Nicholas L., Wiggins, Kerri L., Shriner, Daniel, Veldre, Gudrun, Viigimaa, Margus, Kinra, Sanjay, Prabhakaran, Dorairajan, Tripathy, Vikal, Langefeld, Carl D., Rosengren, Annika, Thelle, Dag S., MariaCorsi, Anna, Singleton, Andrew, Forrester, Terrence, Hilton, Gina, McKenzie, Colin A., Salako, Tunde, Iwai, Naoharu, Kita, Yoshikuni, Ogihara, Toshio, Ohkubo, Takayoshi, Okamura, Tomonori, Ueshima, Hirotsugu, Umemura, Satoshi, Eyheramendy, Susana, Meitinger, Thomas, Wichmann, H.-Erich, Cho, Yoon Shin, Kim, Hyung-Lae, Lee, Jong-Young, Scott, James, Sehmi, Joban S., Zhang, Weihua, Hedblad, Bo, Nilsson, Peter, Smith, George Davey, Wong, Andrew, Narisu, Narisu, Stančáková, Alena, Raffel, Leslie J., Yao, Jie, Kathiresan, Sekar, O'Donnell, Chris, Schwartz, Steven M., Arfan Ikram, M., Longstreth, Will T., Seshadri, Sudha, Shrine, Nick R.G., Wain, Louise V., Morken, Mario A., Swift, Amy J., Laitinen, Jaana, Prokopenko, Inga, Zitting, Paavo, Cooper, Jackie A., Humphries, Steve E., Danesh, John, Rasheed, Asif, Goel, Anuj, Hamsten, Anders, Watkins, Hugh, Bakker, Stephan J.L., van Gilst, Wiek H., Janipalli, Charles S., Radha Mani, K., Yajnik, Chittaranjan S., Hofman, Albert, Mattace-Raso, Francesco U.S., Oostra, Ben A., Demirkan, Ayse, Isaacs, Aaron, Rivadeneira, Fernando, Lakatta, Edward G., Orru, Marco, Scuteri, Angelo, Ala-Korpela, Mika, Kangas, Antti J., Lyytikäinen, Leo-Pekka, Soininen, Pasi, Tukiainen, Taru, Würz, Peter, Twee-Hee Ong, Rick, Dörr, Marcus, Kroemer, Heyo K., Völker, Uwe, Völzke, Henry, Galan, Pilar, Hercberg, Serge, Lathrop, Mark, Zelenika, Diana, Deloukas, Panos, Mangino, Massimo, Spector, Tim D., Zhai, Guangju, Meschia, James F., Nalls, Michael A., Sharma, Pankaj, Terzic, Janos, Kranthi Kumar, M.J., Denniff, Matthew, Zukowska-Szczechowska, Ewa, Wagenknecht, Lynne E., Fowkes, Gerald R., Charchar, Fadi J., Schwarz, Peter E.H., Hayward, Caroline, Guo, Xiuqing, Bots, Michiel L., Brand, Eva, Samani, Nilesh J., Polasek, Ozren, Talmud, Philippa J., Nyberg, Fredrik, Kuh, Diana, Laan, Maris, Hveem, Kristian, Palmer, Lyle J., van der Schouw, Yvonne T., Casas, Juan P., Mohlke, Karen L., Vineis, Paolo, Raitakari, Olli, Wong, Tien Y., Shyong Tai, E., Laakso, Markku, Rao, Dabeeru C., Harris, Tamara B., Morris, Richard W., Dominiczak, Anna F., Kivimaki, Mika, Marmot, Michael G., Miki, Tetsuro, Saleheen, Danish, Chandak, Giriraj R., Coresh, Josef, Navis, Gerjan, Salomaa, Veikko, Han, Bok-Ghee, Kooner, Jaspal S., Melander, Olle, Ridker, Paul M., Bandinelli, Stefania, Gyllensten, Ulf B., Wright, Alan F., Wilson, James F., Ferrucci, Luigi, Farrall, Martin, Tuomilehto, Jaakko, Pramstaller, Peter P., Elosua, Roberto, Soranzo, Nicole, Sijbrands, Eric J.G., Altshuler, David, Loos, Ruth J.F., Shuldiner, Alan R., Gieger, Christian, Meneton, Pierre, Uitterlinden, Andre G., Wareham, Nicholas J., Gudnason, Vilmundur, Rettig, Rainer, Uda, Manuela, Strachan, David P., Witteman, Jacqueline C.M., Hartikainen, Anna-Liisa, Beckmann, Jacques S., Boerwinkle, Eric, Boehnke, Michael, Larson, Martin G., Järvelin, Marjo-Riitta, Psaty, Bruce M., Abecasis, Gonçalo R., Elliott, Paul, van Duijn , Cornelia M., Newton-Cheh, Christopher
Format:	Online
Language:	English
Published:	Oxford University Press 2011
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3090190/

id	pubmed-3090190
recordtype	oai_dc
spelling	pubmed-30901902011-05-10 Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study Fox, Ervin R. Young, J. Hunter Li, Yali Dreisbach, Albert W. Keating, Brendan J. Musani, Solomon K. Liu, Kiang Morrison, Alanna C. Ganesh, Santhi Kutlar, Abdullah Ramachandran, Vasan S. Polak, Josef F. Fabsitz, Richard R. Dries, Daniel L. Farlow, Deborah N. Redline, Susan Adeyemo, Adebowale Hirschorn, Joel N. Sun, Yan V. Wyatt, Sharon B. Penman, Alan D. Palmas, Walter Rotter, Jerome I. Townsend, Raymond R. Doumatey, Ayo P. Tayo, Bamidele O. Mosley, Thomas H. Lyon, Helen N. Kang, Sun J. Rotimi, Charles N. Cooper, Richard S. Franceschini, Nora Curb, J. David Martin, Lisa W. Eaton, Charles B. Kardia, Sharon L.R. Taylor, Herman A. Caulfield, Mark J. Ehret, Georg B. Johnson, Toby Chakravarti, Aravinda Zhu, Xiaofeng Levy, Daniel Munroe, Patricia B. Rice, Kenneth M. Bochud, Murielle Johnson, Andrew D. Chasman, Daniel I. Smith, Albert V. Tobin, Martin D. Verwoert, Germaine C. Hwang, Shih-Jen Pihur, Vasyl Vollenweider, Peter O'Reilly, Paul F. Amin, Najaf Bragg-Gresham, Jennifer L. Teumer, Alexander Glazer, Nicole L. Launer, Lenore Zhao, Jing Hua Aulchenko, Yurii Heath, Simon Sõber, Siim Parsa, Afshin Luan, Jian'an Arora, Pankaj Dehghan, Abbas Zhang, Feng Lucas, Gavin Hicks, Andrew A. Jackson, Anne U. Peden, John F. Tanaka, Toshiko Wild, Sarah H. Rudan, Igor Igl, Wilmar Milaneschi, Yuri Parker, Alex N. Fava, Cristiano Chambers, John C. Kumari, Meena JinGo, Min van der Harst, Pim Kao, Wen Hong Linda Sjögren, Marketa Vinay, D.G. Alexander, Myriam Tabara, Yasuharu Shaw-Hawkins, Sue Whincup, Peter H. Liu, Yongmei Shi, Gang Kuusisto, Johanna Seielstad, Mark Sim, Xueling Nguyen, Khanh-Dung Hoang Lehtimäki, Terho Matullo, Giuseppe Wu, Ying Gaunt, Tom R. Charlotte Onland-Moret, N. Cooper, Matthew N. Platou, Carl G.P. Org, Elin Hardy, Rebecca Dahgam, Santosh Palmen, Jutta Vitart, Veronique Braund, Peter S. Kuznetsova, Tatiana Uiterwaal, Cuno S.P.M. Campbell, Harry Ludwig, Barbara Tomaszewski, Maciej Tzoulaki, Ioanna Palmer, Nicholette D. Aspelund, Thor Garcia, Melissa Chang, Yen-Pei C. O'Connell, Jeffrey R. Steinle, Nanette I. Grobbee, Diederick E. Arking, Dan E. Hernandez, Dena Najjar, Samer McArdle, Wendy L. Hadley, David Brown, Morris J. Connell, John M. Hingorani, Aroon D. Day, Ian N.M. Lawlor, Debbie A. Beilby, John P. Lawrence, Robert W. Clarke, Robert Collins, Rory Hopewell, Jemma C. Ongen, Halit Bis, Joshua C. Kähönen, Mika Viikari, Jorma Adair, Linda S. Lee, Nanette R. Chen, Ming-Huei Olden, Matthias Pattaro, Cristian Hoffman Bolton, Judith A. Köttgen, Anna Bergmann, Sven Mooser, Vincent Chaturvedi, Nish Frayling, Timothy M. Islam, Muhammad Jafar, Tazeen H. Erdmann, Jeanette Kulkarni, Smita R. Bornstein, Stefan R. Grässler, Jürgen Groop, Leif Voight, Benjamin F. Kettunen, Johannes Howard, Philip Taylor, Andrew Guarrera, Simonetta Ricceri, Fulvio Emilsson, Valur Plump, Andrew Barroso, Inês Khaw, Kay-Tee Weder, Alan B. Hunt, Steven C. Bergman, Richard N. Collins, Francis S. Bonnycastle, Lori L. Scott, Laura J. Stringham, Heather M. Peltonen, Leena Perola, Markus Vartiainen, Erkki Brand, Stefan-Martin Staessen, Jan A. Wang, Thomas J. Burton, Paul R. SolerArtigas, Maria Dong, Yanbin Snieder, Harold Wang, Xiaoling Zhu, Haidong Lohman, Kurt K. Rudock, Megan E. Heckbert, Susan R. Smith, Nicholas L. Wiggins, Kerri L. Shriner, Daniel Veldre, Gudrun Viigimaa, Margus Kinra, Sanjay Prabhakaran, Dorairajan Tripathy, Vikal Langefeld, Carl D. Rosengren, Annika Thelle, Dag S. MariaCorsi, Anna Singleton, Andrew Forrester, Terrence Hilton, Gina McKenzie, Colin A. Salako, Tunde Iwai, Naoharu Kita, Yoshikuni Ogihara, Toshio Ohkubo, Takayoshi Okamura, Tomonori Ueshima, Hirotsugu Umemura, Satoshi Eyheramendy, Susana Meitinger, Thomas Wichmann, H.-Erich Cho, Yoon Shin Kim, Hyung-Lae Lee, Jong-Young Scott, James Sehmi, Joban S. Zhang, Weihua Hedblad, Bo Nilsson, Peter Smith, George Davey Wong, Andrew Narisu, Narisu Stančáková, Alena Raffel, Leslie J. Yao, Jie Kathiresan, Sekar O'Donnell, Chris Schwartz, Steven M. Arfan Ikram, M. Longstreth, Will T. Seshadri, Sudha Shrine, Nick R.G. Wain, Louise V. Morken, Mario A. Swift, Amy J. Laitinen, Jaana Prokopenko, Inga Zitting, Paavo Cooper, Jackie A. Humphries, Steve E. Danesh, John Rasheed, Asif Goel, Anuj Hamsten, Anders Watkins, Hugh Bakker, Stephan J.L. van Gilst, Wiek H. Janipalli, Charles S. Radha Mani, K. Yajnik, Chittaranjan S. Hofman, Albert Mattace-Raso, Francesco U.S. Oostra, Ben A. Demirkan, Ayse Isaacs, Aaron Rivadeneira, Fernando Lakatta, Edward G. Orru, Marco Scuteri, Angelo Ala-Korpela, Mika Kangas, Antti J. Lyytikäinen, Leo-Pekka Soininen, Pasi Tukiainen, Taru Würz, Peter Twee-Hee Ong, Rick Dörr, Marcus Kroemer, Heyo K. Völker, Uwe Völzke, Henry Galan, Pilar Hercberg, Serge Lathrop, Mark Zelenika, Diana Deloukas, Panos Mangino, Massimo Spector, Tim D. Zhai, Guangju Meschia, James F. Nalls, Michael A. Sharma, Pankaj Terzic, Janos Kranthi Kumar, M.J. Denniff, Matthew Zukowska-Szczechowska, Ewa Wagenknecht, Lynne E. Fowkes, Gerald R. Charchar, Fadi J. Schwarz, Peter E.H. Hayward, Caroline Guo, Xiuqing Bots, Michiel L. Brand, Eva Samani, Nilesh J. Polasek, Ozren Talmud, Philippa J. Nyberg, Fredrik Kuh, Diana Laan, Maris Hveem, Kristian Palmer, Lyle J. van der Schouw, Yvonne T. Casas, Juan P. Mohlke, Karen L. Vineis, Paolo Raitakari, Olli Wong, Tien Y. Shyong Tai, E. Laakso, Markku Rao, Dabeeru C. Harris, Tamara B. Morris, Richard W. Dominiczak, Anna F. Kivimaki, Mika Marmot, Michael G. Miki, Tetsuro Saleheen, Danish Chandak, Giriraj R. Coresh, Josef Navis, Gerjan Salomaa, Veikko Han, Bok-Ghee Kooner, Jaspal S. Melander, Olle Ridker, Paul M. Bandinelli, Stefania Gyllensten, Ulf B. Wright, Alan F. Wilson, James F. Ferrucci, Luigi Farrall, Martin Tuomilehto, Jaakko Pramstaller, Peter P. Elosua, Roberto Soranzo, Nicole Sijbrands, Eric J.G. Altshuler, David Loos, Ruth J.F. Shuldiner, Alan R. Gieger, Christian Meneton, Pierre Uitterlinden, Andre G. Wareham, Nicholas J. Gudnason, Vilmundur Rettig, Rainer Uda, Manuela Strachan, David P. Witteman, Jacqueline C.M. Hartikainen, Anna-Liisa Beckmann, Jacques S. Boerwinkle, Eric Boehnke, Michael Larson, Martin G. Järvelin, Marjo-Riitta Psaty, Bruce M. Abecasis, Gonçalo R. Elliott, Paul van Duijn , Cornelia M. Newton-Cheh, Christopher Association Studies Articles The prevalence of hypertension in African Americans (AAs) is higher than in other US groups; yet, few have performed genome-wide association studies (GWASs) in AA. Among people of European descent, GWASs have identified genetic variants at 13 loci that are associated with blood pressure. It is unknown if these variants confer susceptibility in people of African ancestry. Here, we examined genome-wide and candidate gene associations with systolic blood pressure (SBP) and diastolic blood pressure (DBP) using the Candidate Gene Association Resource (CARe) consortium consisting of 8591 AAs. Genotypes included genome-wide single-nucleotide polymorphism (SNP) data utilizing the Affymetrix 6.0 array with imputation to 2.5 million HapMap SNPs and candidate gene SNP data utilizing a 50K cardiovascular gene-centric array (ITMAT-Broad-CARe [IBC] array). For Affymetrix data, the strongest signal for DBP was rs10474346 (P= 3.6 × 10−8) located near GPR98 and ARRDC3. For SBP, the strongest signal was rs2258119 in C21orf91 (P= 4.7 × 10−8). The top IBC association for SBP was rs2012318 (P= 6.4 × 10−6) near SLC25A42 and for DBP was rs2523586 (P= 1.3 × 10−6) near HLA-B. None of the top variants replicated in additional AA (n = 11 882) or European-American (n = 69 899) cohorts. We replicated previously reported European-American blood pressure SNPs in our AA samples (SH2B3, P= 0.009; TBX3-TBX5, P= 0.03; and CSK-ULK3, P= 0.0004). These genetic loci represent the best evidence of genetic influences on SBP and DBP in AAs to date. More broadly, this work supports that notion that blood pressure among AAs is a trait with genetic underpinnings but also with significant complexity. Oxford University Press 2011-06-01 2011-03-04 /pmc/articles/PMC3090190/ /pubmed/21378095 http://dx.doi.org/10.1093/hmg/ddr092 Text en © The Author 2011. Published by Oxford University Press. http://creativecommons.org/licenses/by-nc/2.5/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Fox, Ervin R. Young, J. Hunter Li, Yali Dreisbach, Albert W. Keating, Brendan J. Musani, Solomon K. Liu, Kiang Morrison, Alanna C. Ganesh, Santhi Kutlar, Abdullah Ramachandran, Vasan S. Polak, Josef F. Fabsitz, Richard R. Dries, Daniel L. Farlow, Deborah N. Redline, Susan Adeyemo, Adebowale Hirschorn, Joel N. Sun, Yan V. Wyatt, Sharon B. Penman, Alan D. Palmas, Walter Rotter, Jerome I. Townsend, Raymond R. Doumatey, Ayo P. Tayo, Bamidele O. Mosley, Thomas H. Lyon, Helen N. Kang, Sun J. Rotimi, Charles N. Cooper, Richard S. Franceschini, Nora Curb, J. David Martin, Lisa W. Eaton, Charles B. Kardia, Sharon L.R. Taylor, Herman A. Caulfield, Mark J. Ehret, Georg B. Johnson, Toby Chakravarti, Aravinda Zhu, Xiaofeng Levy, Daniel Munroe, Patricia B. Rice, Kenneth M. Bochud, Murielle Johnson, Andrew D. Chasman, Daniel I. Smith, Albert V. Tobin, Martin D. Verwoert, Germaine C. Hwang, Shih-Jen Pihur, Vasyl Vollenweider, Peter O'Reilly, Paul F. Amin, Najaf Bragg-Gresham, Jennifer L. Teumer, Alexander Glazer, Nicole L. Launer, Lenore Zhao, Jing Hua Aulchenko, Yurii Heath, Simon Sõber, Siim Parsa, Afshin Luan, Jian'an Arora, Pankaj Dehghan, Abbas Zhang, Feng Lucas, Gavin Hicks, Andrew A. Jackson, Anne U. Peden, John F. Tanaka, Toshiko Wild, Sarah H. Rudan, Igor Igl, Wilmar Milaneschi, Yuri Parker, Alex N. Fava, Cristiano Chambers, John C. Kumari, Meena JinGo, Min van der Harst, Pim Kao, Wen Hong Linda Sjögren, Marketa Vinay, D.G. Alexander, Myriam Tabara, Yasuharu Shaw-Hawkins, Sue Whincup, Peter H. Liu, Yongmei Shi, Gang Kuusisto, Johanna Seielstad, Mark Sim, Xueling Nguyen, Khanh-Dung Hoang Lehtimäki, Terho Matullo, Giuseppe Wu, Ying Gaunt, Tom R. Charlotte Onland-Moret, N. Cooper, Matthew N. Platou, Carl G.P. Org, Elin Hardy, Rebecca Dahgam, Santosh Palmen, Jutta Vitart, Veronique Braund, Peter S. Kuznetsova, Tatiana Uiterwaal, Cuno S.P.M. Campbell, Harry Ludwig, Barbara Tomaszewski, Maciej Tzoulaki, Ioanna Palmer, Nicholette D. Aspelund, Thor Garcia, Melissa Chang, Yen-Pei C. O'Connell, Jeffrey R. Steinle, Nanette I. Grobbee, Diederick E. Arking, Dan E. Hernandez, Dena Najjar, Samer McArdle, Wendy L. Hadley, David Brown, Morris J. Connell, John M. Hingorani, Aroon D. Day, Ian N.M. Lawlor, Debbie A. Beilby, John P. Lawrence, Robert W. Clarke, Robert Collins, Rory Hopewell, Jemma C. Ongen, Halit Bis, Joshua C. Kähönen, Mika Viikari, Jorma Adair, Linda S. Lee, Nanette R. Chen, Ming-Huei Olden, Matthias Pattaro, Cristian Hoffman Bolton, Judith A. Köttgen, Anna Bergmann, Sven Mooser, Vincent Chaturvedi, Nish Frayling, Timothy M. Islam, Muhammad Jafar, Tazeen H. Erdmann, Jeanette Kulkarni, Smita R. Bornstein, Stefan R. Grässler, Jürgen Groop, Leif Voight, Benjamin F. Kettunen, Johannes Howard, Philip Taylor, Andrew Guarrera, Simonetta Ricceri, Fulvio Emilsson, Valur Plump, Andrew Barroso, Inês Khaw, Kay-Tee Weder, Alan B. Hunt, Steven C. Bergman, Richard N. Collins, Francis S. Bonnycastle, Lori L. Scott, Laura J. Stringham, Heather M. Peltonen, Leena Perola, Markus Vartiainen, Erkki Brand, Stefan-Martin Staessen, Jan A. Wang, Thomas J. Burton, Paul R. SolerArtigas, Maria Dong, Yanbin Snieder, Harold Wang, Xiaoling Zhu, Haidong Lohman, Kurt K. Rudock, Megan E. Heckbert, Susan R. Smith, Nicholas L. Wiggins, Kerri L. Shriner, Daniel Veldre, Gudrun Viigimaa, Margus Kinra, Sanjay Prabhakaran, Dorairajan Tripathy, Vikal Langefeld, Carl D. Rosengren, Annika Thelle, Dag S. MariaCorsi, Anna Singleton, Andrew Forrester, Terrence Hilton, Gina McKenzie, Colin A. Salako, Tunde Iwai, Naoharu Kita, Yoshikuni Ogihara, Toshio Ohkubo, Takayoshi Okamura, Tomonori Ueshima, Hirotsugu Umemura, Satoshi Eyheramendy, Susana Meitinger, Thomas Wichmann, H.-Erich Cho, Yoon Shin Kim, Hyung-Lae Lee, Jong-Young Scott, James Sehmi, Joban S. Zhang, Weihua Hedblad, Bo Nilsson, Peter Smith, George Davey Wong, Andrew Narisu, Narisu Stančáková, Alena Raffel, Leslie J. Yao, Jie Kathiresan, Sekar O'Donnell, Chris Schwartz, Steven M. Arfan Ikram, M. Longstreth, Will T. Seshadri, Sudha Shrine, Nick R.G. Wain, Louise V. Morken, Mario A. Swift, Amy J. Laitinen, Jaana Prokopenko, Inga Zitting, Paavo Cooper, Jackie A. Humphries, Steve E. Danesh, John Rasheed, Asif Goel, Anuj Hamsten, Anders Watkins, Hugh Bakker, Stephan J.L. van Gilst, Wiek H. Janipalli, Charles S. Radha Mani, K. Yajnik, Chittaranjan S. Hofman, Albert Mattace-Raso, Francesco U.S. Oostra, Ben A. Demirkan, Ayse Isaacs, Aaron Rivadeneira, Fernando Lakatta, Edward G. Orru, Marco Scuteri, Angelo Ala-Korpela, Mika Kangas, Antti J. Lyytikäinen, Leo-Pekka Soininen, Pasi Tukiainen, Taru Würz, Peter Twee-Hee Ong, Rick Dörr, Marcus Kroemer, Heyo K. Völker, Uwe Völzke, Henry Galan, Pilar Hercberg, Serge Lathrop, Mark Zelenika, Diana Deloukas, Panos Mangino, Massimo Spector, Tim D. Zhai, Guangju Meschia, James F. Nalls, Michael A. Sharma, Pankaj Terzic, Janos Kranthi Kumar, M.J. Denniff, Matthew Zukowska-Szczechowska, Ewa Wagenknecht, Lynne E. Fowkes, Gerald R. Charchar, Fadi J. Schwarz, Peter E.H. Hayward, Caroline Guo, Xiuqing Bots, Michiel L. Brand, Eva Samani, Nilesh J. Polasek, Ozren Talmud, Philippa J. Nyberg, Fredrik Kuh, Diana Laan, Maris Hveem, Kristian Palmer, Lyle J. van der Schouw, Yvonne T. Casas, Juan P. Mohlke, Karen L. Vineis, Paolo Raitakari, Olli Wong, Tien Y. Shyong Tai, E. Laakso, Markku Rao, Dabeeru C. Harris, Tamara B. Morris, Richard W. Dominiczak, Anna F. Kivimaki, Mika Marmot, Michael G. Miki, Tetsuro Saleheen, Danish Chandak, Giriraj R. Coresh, Josef Navis, Gerjan Salomaa, Veikko Han, Bok-Ghee Kooner, Jaspal S. Melander, Olle Ridker, Paul M. Bandinelli, Stefania Gyllensten, Ulf B. Wright, Alan F. Wilson, James F. Ferrucci, Luigi Farrall, Martin Tuomilehto, Jaakko Pramstaller, Peter P. Elosua, Roberto Soranzo, Nicole Sijbrands, Eric J.G. Altshuler, David Loos, Ruth J.F. Shuldiner, Alan R. Gieger, Christian Meneton, Pierre Uitterlinden, Andre G. Wareham, Nicholas J. Gudnason, Vilmundur Rettig, Rainer Uda, Manuela Strachan, David P. Witteman, Jacqueline C.M. Hartikainen, Anna-Liisa Beckmann, Jacques S. Boerwinkle, Eric Boehnke, Michael Larson, Martin G. Järvelin, Marjo-Riitta Psaty, Bruce M. Abecasis, Gonçalo R. Elliott, Paul van Duijn , Cornelia M. Newton-Cheh, Christopher
spellingShingle	Fox, Ervin R. Young, J. Hunter Li, Yali Dreisbach, Albert W. Keating, Brendan J. Musani, Solomon K. Liu, Kiang Morrison, Alanna C. Ganesh, Santhi Kutlar, Abdullah Ramachandran, Vasan S. Polak, Josef F. Fabsitz, Richard R. Dries, Daniel L. Farlow, Deborah N. Redline, Susan Adeyemo, Adebowale Hirschorn, Joel N. Sun, Yan V. Wyatt, Sharon B. Penman, Alan D. Palmas, Walter Rotter, Jerome I. Townsend, Raymond R. Doumatey, Ayo P. Tayo, Bamidele O. Mosley, Thomas H. Lyon, Helen N. Kang, Sun J. Rotimi, Charles N. Cooper, Richard S. Franceschini, Nora Curb, J. David Martin, Lisa W. Eaton, Charles B. Kardia, Sharon L.R. Taylor, Herman A. Caulfield, Mark J. Ehret, Georg B. Johnson, Toby Chakravarti, Aravinda Zhu, Xiaofeng Levy, Daniel Munroe, Patricia B. Rice, Kenneth M. Bochud, Murielle Johnson, Andrew D. Chasman, Daniel I. Smith, Albert V. Tobin, Martin D. Verwoert, Germaine C. Hwang, Shih-Jen Pihur, Vasyl Vollenweider, Peter O'Reilly, Paul F. Amin, Najaf Bragg-Gresham, Jennifer L. Teumer, Alexander Glazer, Nicole L. Launer, Lenore Zhao, Jing Hua Aulchenko, Yurii Heath, Simon Sõber, Siim Parsa, Afshin Luan, Jian'an Arora, Pankaj Dehghan, Abbas Zhang, Feng Lucas, Gavin Hicks, Andrew A. Jackson, Anne U. Peden, John F. Tanaka, Toshiko Wild, Sarah H. Rudan, Igor Igl, Wilmar Milaneschi, Yuri Parker, Alex N. Fava, Cristiano Chambers, John C. Kumari, Meena JinGo, Min van der Harst, Pim Kao, Wen Hong Linda Sjögren, Marketa Vinay, D.G. Alexander, Myriam Tabara, Yasuharu Shaw-Hawkins, Sue Whincup, Peter H. Liu, Yongmei Shi, Gang Kuusisto, Johanna Seielstad, Mark Sim, Xueling Nguyen, Khanh-Dung Hoang Lehtimäki, Terho Matullo, Giuseppe Wu, Ying Gaunt, Tom R. Charlotte Onland-Moret, N. Cooper, Matthew N. Platou, Carl G.P. Org, Elin Hardy, Rebecca Dahgam, Santosh Palmen, Jutta Vitart, Veronique Braund, Peter S. Kuznetsova, Tatiana Uiterwaal, Cuno S.P.M. Campbell, Harry Ludwig, Barbara Tomaszewski, Maciej Tzoulaki, Ioanna Palmer, Nicholette D. Aspelund, Thor Garcia, Melissa Chang, Yen-Pei C. O'Connell, Jeffrey R. Steinle, Nanette I. Grobbee, Diederick E. Arking, Dan E. Hernandez, Dena Najjar, Samer McArdle, Wendy L. Hadley, David Brown, Morris J. Connell, John M. Hingorani, Aroon D. Day, Ian N.M. Lawlor, Debbie A. Beilby, John P. Lawrence, Robert W. Clarke, Robert Collins, Rory Hopewell, Jemma C. Ongen, Halit Bis, Joshua C. Kähönen, Mika Viikari, Jorma Adair, Linda S. Lee, Nanette R. Chen, Ming-Huei Olden, Matthias Pattaro, Cristian Hoffman Bolton, Judith A. Köttgen, Anna Bergmann, Sven Mooser, Vincent Chaturvedi, Nish Frayling, Timothy M. Islam, Muhammad Jafar, Tazeen H. Erdmann, Jeanette Kulkarni, Smita R. Bornstein, Stefan R. Grässler, Jürgen Groop, Leif Voight, Benjamin F. Kettunen, Johannes Howard, Philip Taylor, Andrew Guarrera, Simonetta Ricceri, Fulvio Emilsson, Valur Plump, Andrew Barroso, Inês Khaw, Kay-Tee Weder, Alan B. Hunt, Steven C. Bergman, Richard N. Collins, Francis S. Bonnycastle, Lori L. Scott, Laura J. Stringham, Heather M. Peltonen, Leena Perola, Markus Vartiainen, Erkki Brand, Stefan-Martin Staessen, Jan A. Wang, Thomas J. Burton, Paul R. SolerArtigas, Maria Dong, Yanbin Snieder, Harold Wang, Xiaoling Zhu, Haidong Lohman, Kurt K. Rudock, Megan E. Heckbert, Susan R. Smith, Nicholas L. Wiggins, Kerri L. Shriner, Daniel Veldre, Gudrun Viigimaa, Margus Kinra, Sanjay Prabhakaran, Dorairajan Tripathy, Vikal Langefeld, Carl D. Rosengren, Annika Thelle, Dag S. MariaCorsi, Anna Singleton, Andrew Forrester, Terrence Hilton, Gina McKenzie, Colin A. Salako, Tunde Iwai, Naoharu Kita, Yoshikuni Ogihara, Toshio Ohkubo, Takayoshi Okamura, Tomonori Ueshima, Hirotsugu Umemura, Satoshi Eyheramendy, Susana Meitinger, Thomas Wichmann, H.-Erich Cho, Yoon Shin Kim, Hyung-Lae Lee, Jong-Young Scott, James Sehmi, Joban S. Zhang, Weihua Hedblad, Bo Nilsson, Peter Smith, George Davey Wong, Andrew Narisu, Narisu Stančáková, Alena Raffel, Leslie J. Yao, Jie Kathiresan, Sekar O'Donnell, Chris Schwartz, Steven M. Arfan Ikram, M. Longstreth, Will T. Seshadri, Sudha Shrine, Nick R.G. Wain, Louise V. Morken, Mario A. Swift, Amy J. Laitinen, Jaana Prokopenko, Inga Zitting, Paavo Cooper, Jackie A. Humphries, Steve E. Danesh, John Rasheed, Asif Goel, Anuj Hamsten, Anders Watkins, Hugh Bakker, Stephan J.L. van Gilst, Wiek H. Janipalli, Charles S. Radha Mani, K. Yajnik, Chittaranjan S. Hofman, Albert Mattace-Raso, Francesco U.S. Oostra, Ben A. Demirkan, Ayse Isaacs, Aaron Rivadeneira, Fernando Lakatta, Edward G. Orru, Marco Scuteri, Angelo Ala-Korpela, Mika Kangas, Antti J. Lyytikäinen, Leo-Pekka Soininen, Pasi Tukiainen, Taru Würz, Peter Twee-Hee Ong, Rick Dörr, Marcus Kroemer, Heyo K. Völker, Uwe Völzke, Henry Galan, Pilar Hercberg, Serge Lathrop, Mark Zelenika, Diana Deloukas, Panos Mangino, Massimo Spector, Tim D. Zhai, Guangju Meschia, James F. Nalls, Michael A. Sharma, Pankaj Terzic, Janos Kranthi Kumar, M.J. Denniff, Matthew Zukowska-Szczechowska, Ewa Wagenknecht, Lynne E. Fowkes, Gerald R. Charchar, Fadi J. Schwarz, Peter E.H. Hayward, Caroline Guo, Xiuqing Bots, Michiel L. Brand, Eva Samani, Nilesh J. Polasek, Ozren Talmud, Philippa J. Nyberg, Fredrik Kuh, Diana Laan, Maris Hveem, Kristian Palmer, Lyle J. van der Schouw, Yvonne T. Casas, Juan P. Mohlke, Karen L. Vineis, Paolo Raitakari, Olli Wong, Tien Y. Shyong Tai, E. Laakso, Markku Rao, Dabeeru C. Harris, Tamara B. Morris, Richard W. Dominiczak, Anna F. Kivimaki, Mika Marmot, Michael G. Miki, Tetsuro Saleheen, Danish Chandak, Giriraj R. Coresh, Josef Navis, Gerjan Salomaa, Veikko Han, Bok-Ghee Kooner, Jaspal S. Melander, Olle Ridker, Paul M. Bandinelli, Stefania Gyllensten, Ulf B. Wright, Alan F. Wilson, James F. Ferrucci, Luigi Farrall, Martin Tuomilehto, Jaakko Pramstaller, Peter P. Elosua, Roberto Soranzo, Nicole Sijbrands, Eric J.G. Altshuler, David Loos, Ruth J.F. Shuldiner, Alan R. Gieger, Christian Meneton, Pierre Uitterlinden, Andre G. Wareham, Nicholas J. Gudnason, Vilmundur Rettig, Rainer Uda, Manuela Strachan, David P. Witteman, Jacqueline C.M. Hartikainen, Anna-Liisa Beckmann, Jacques S. Boerwinkle, Eric Boehnke, Michael Larson, Martin G. Järvelin, Marjo-Riitta Psaty, Bruce M. Abecasis, Gonçalo R. Elliott, Paul van Duijn , Cornelia M. Newton-Cheh, Christopher Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study
author_facet	Fox, Ervin R. Young, J. Hunter Li, Yali Dreisbach, Albert W. Keating, Brendan J. Musani, Solomon K. Liu, Kiang Morrison, Alanna C. Ganesh, Santhi Kutlar, Abdullah Ramachandran, Vasan S. Polak, Josef F. Fabsitz, Richard R. Dries, Daniel L. Farlow, Deborah N. Redline, Susan Adeyemo, Adebowale Hirschorn, Joel N. Sun, Yan V. Wyatt, Sharon B. Penman, Alan D. Palmas, Walter Rotter, Jerome I. Townsend, Raymond R. Doumatey, Ayo P. Tayo, Bamidele O. Mosley, Thomas H. Lyon, Helen N. Kang, Sun J. Rotimi, Charles N. Cooper, Richard S. Franceschini, Nora Curb, J. David Martin, Lisa W. Eaton, Charles B. Kardia, Sharon L.R. Taylor, Herman A. Caulfield, Mark J. Ehret, Georg B. Johnson, Toby Chakravarti, Aravinda Zhu, Xiaofeng Levy, Daniel Munroe, Patricia B. Rice, Kenneth M. Bochud, Murielle Johnson, Andrew D. Chasman, Daniel I. Smith, Albert V. Tobin, Martin D. Verwoert, Germaine C. Hwang, Shih-Jen Pihur, Vasyl Vollenweider, Peter O'Reilly, Paul F. Amin, Najaf Bragg-Gresham, Jennifer L. Teumer, Alexander Glazer, Nicole L. Launer, Lenore Zhao, Jing Hua Aulchenko, Yurii Heath, Simon Sõber, Siim Parsa, Afshin Luan, Jian'an Arora, Pankaj Dehghan, Abbas Zhang, Feng Lucas, Gavin Hicks, Andrew A. Jackson, Anne U. Peden, John F. Tanaka, Toshiko Wild, Sarah H. Rudan, Igor Igl, Wilmar Milaneschi, Yuri Parker, Alex N. Fava, Cristiano Chambers, John C. Kumari, Meena JinGo, Min van der Harst, Pim Kao, Wen Hong Linda Sjögren, Marketa Vinay, D.G. Alexander, Myriam Tabara, Yasuharu Shaw-Hawkins, Sue Whincup, Peter H. Liu, Yongmei Shi, Gang Kuusisto, Johanna Seielstad, Mark Sim, Xueling Nguyen, Khanh-Dung Hoang Lehtimäki, Terho Matullo, Giuseppe Wu, Ying Gaunt, Tom R. Charlotte Onland-Moret, N. Cooper, Matthew N. Platou, Carl G.P. Org, Elin Hardy, Rebecca Dahgam, Santosh Palmen, Jutta Vitart, Veronique Braund, Peter S. Kuznetsova, Tatiana Uiterwaal, Cuno S.P.M. Campbell, Harry Ludwig, Barbara Tomaszewski, Maciej Tzoulaki, Ioanna Palmer, Nicholette D. Aspelund, Thor Garcia, Melissa Chang, Yen-Pei C. O'Connell, Jeffrey R. Steinle, Nanette I. Grobbee, Diederick E. Arking, Dan E. Hernandez, Dena Najjar, Samer McArdle, Wendy L. Hadley, David Brown, Morris J. Connell, John M. Hingorani, Aroon D. Day, Ian N.M. Lawlor, Debbie A. Beilby, John P. Lawrence, Robert W. Clarke, Robert Collins, Rory Hopewell, Jemma C. Ongen, Halit Bis, Joshua C. Kähönen, Mika Viikari, Jorma Adair, Linda S. Lee, Nanette R. Chen, Ming-Huei Olden, Matthias Pattaro, Cristian Hoffman Bolton, Judith A. Köttgen, Anna Bergmann, Sven Mooser, Vincent Chaturvedi, Nish Frayling, Timothy M. Islam, Muhammad Jafar, Tazeen H. Erdmann, Jeanette Kulkarni, Smita R. Bornstein, Stefan R. Grässler, Jürgen Groop, Leif Voight, Benjamin F. Kettunen, Johannes Howard, Philip Taylor, Andrew Guarrera, Simonetta Ricceri, Fulvio Emilsson, Valur Plump, Andrew Barroso, Inês Khaw, Kay-Tee Weder, Alan B. Hunt, Steven C. Bergman, Richard N. Collins, Francis S. Bonnycastle, Lori L. Scott, Laura J. Stringham, Heather M. Peltonen, Leena Perola, Markus Vartiainen, Erkki Brand, Stefan-Martin Staessen, Jan A. Wang, Thomas J. Burton, Paul R. SolerArtigas, Maria Dong, Yanbin Snieder, Harold Wang, Xiaoling Zhu, Haidong Lohman, Kurt K. Rudock, Megan E. Heckbert, Susan R. Smith, Nicholas L. Wiggins, Kerri L. Shriner, Daniel Veldre, Gudrun Viigimaa, Margus Kinra, Sanjay Prabhakaran, Dorairajan Tripathy, Vikal Langefeld, Carl D. Rosengren, Annika Thelle, Dag S. MariaCorsi, Anna Singleton, Andrew Forrester, Terrence Hilton, Gina McKenzie, Colin A. Salako, Tunde Iwai, Naoharu Kita, Yoshikuni Ogihara, Toshio Ohkubo, Takayoshi Okamura, Tomonori Ueshima, Hirotsugu Umemura, Satoshi Eyheramendy, Susana Meitinger, Thomas Wichmann, H.-Erich Cho, Yoon Shin Kim, Hyung-Lae Lee, Jong-Young Scott, James Sehmi, Joban S. Zhang, Weihua Hedblad, Bo Nilsson, Peter Smith, George Davey Wong, Andrew Narisu, Narisu Stančáková, Alena Raffel, Leslie J. Yao, Jie Kathiresan, Sekar O'Donnell, Chris Schwartz, Steven M. Arfan Ikram, M. Longstreth, Will T. Seshadri, Sudha Shrine, Nick R.G. Wain, Louise V. Morken, Mario A. Swift, Amy J. Laitinen, Jaana Prokopenko, Inga Zitting, Paavo Cooper, Jackie A. Humphries, Steve E. Danesh, John Rasheed, Asif Goel, Anuj Hamsten, Anders Watkins, Hugh Bakker, Stephan J.L. van Gilst, Wiek H. Janipalli, Charles S. Radha Mani, K. Yajnik, Chittaranjan S. Hofman, Albert Mattace-Raso, Francesco U.S. Oostra, Ben A. Demirkan, Ayse Isaacs, Aaron Rivadeneira, Fernando Lakatta, Edward G. Orru, Marco Scuteri, Angelo Ala-Korpela, Mika Kangas, Antti J. Lyytikäinen, Leo-Pekka Soininen, Pasi Tukiainen, Taru Würz, Peter Twee-Hee Ong, Rick Dörr, Marcus Kroemer, Heyo K. Völker, Uwe Völzke, Henry Galan, Pilar Hercberg, Serge Lathrop, Mark Zelenika, Diana Deloukas, Panos Mangino, Massimo Spector, Tim D. Zhai, Guangju Meschia, James F. Nalls, Michael A. Sharma, Pankaj Terzic, Janos Kranthi Kumar, M.J. Denniff, Matthew Zukowska-Szczechowska, Ewa Wagenknecht, Lynne E. Fowkes, Gerald R. Charchar, Fadi J. Schwarz, Peter E.H. Hayward, Caroline Guo, Xiuqing Bots, Michiel L. Brand, Eva Samani, Nilesh J. Polasek, Ozren Talmud, Philippa J. Nyberg, Fredrik Kuh, Diana Laan, Maris Hveem, Kristian Palmer, Lyle J. van der Schouw, Yvonne T. Casas, Juan P. Mohlke, Karen L. Vineis, Paolo Raitakari, Olli Wong, Tien Y. Shyong Tai, E. Laakso, Markku Rao, Dabeeru C. Harris, Tamara B. Morris, Richard W. Dominiczak, Anna F. Kivimaki, Mika Marmot, Michael G. Miki, Tetsuro Saleheen, Danish Chandak, Giriraj R. Coresh, Josef Navis, Gerjan Salomaa, Veikko Han, Bok-Ghee Kooner, Jaspal S. Melander, Olle Ridker, Paul M. Bandinelli, Stefania Gyllensten, Ulf B. Wright, Alan F. Wilson, James F. Ferrucci, Luigi Farrall, Martin Tuomilehto, Jaakko Pramstaller, Peter P. Elosua, Roberto Soranzo, Nicole Sijbrands, Eric J.G. Altshuler, David Loos, Ruth J.F. Shuldiner, Alan R. Gieger, Christian Meneton, Pierre Uitterlinden, Andre G. Wareham, Nicholas J. Gudnason, Vilmundur Rettig, Rainer Uda, Manuela Strachan, David P. Witteman, Jacqueline C.M. Hartikainen, Anna-Liisa Beckmann, Jacques S. Boerwinkle, Eric Boehnke, Michael Larson, Martin G. Järvelin, Marjo-Riitta Psaty, Bruce M. Abecasis, Gonçalo R. Elliott, Paul van Duijn , Cornelia M. Newton-Cheh, Christopher
author_sort	Fox, Ervin R.
title	Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study
title_short	Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study
title_full	Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study
title_fullStr	Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study
title_full_unstemmed	Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study
title_sort	association of genetic variation with systolic and diastolic blood pressure among african americans: the candidate gene association resource study
description	The prevalence of hypertension in African Americans (AAs) is higher than in other US groups; yet, few have performed genome-wide association studies (GWASs) in AA. Among people of European descent, GWASs have identified genetic variants at 13 loci that are associated with blood pressure. It is unknown if these variants confer susceptibility in people of African ancestry. Here, we examined genome-wide and candidate gene associations with systolic blood pressure (SBP) and diastolic blood pressure (DBP) using the Candidate Gene Association Resource (CARe) consortium consisting of 8591 AAs. Genotypes included genome-wide single-nucleotide polymorphism (SNP) data utilizing the Affymetrix 6.0 array with imputation to 2.5 million HapMap SNPs and candidate gene SNP data utilizing a 50K cardiovascular gene-centric array (ITMAT-Broad-CARe [IBC] array). For Affymetrix data, the strongest signal for DBP was rs10474346 (P= 3.6 × 10−8) located near GPR98 and ARRDC3. For SBP, the strongest signal was rs2258119 in C21orf91 (P= 4.7 × 10−8). The top IBC association for SBP was rs2012318 (P= 6.4 × 10−6) near SLC25A42 and for DBP was rs2523586 (P= 1.3 × 10−6) near HLA-B. None of the top variants replicated in additional AA (n = 11 882) or European-American (n = 69 899) cohorts. We replicated previously reported European-American blood pressure SNPs in our AA samples (SH2B3, P= 0.009; TBX3-TBX5, P= 0.03; and CSK-ULK3, P= 0.0004). These genetic loci represent the best evidence of genetic influences on SBP and DBP in AAs to date. More broadly, this work supports that notion that blood pressure among AAs is a trait with genetic underpinnings but also with significant complexity.
publisher	Oxford University Press
publishDate	2011
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3090190/
_version_	1611452638622121984

Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study

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