lncRNAs transactivate Staufen1-mediated mRNA decay by duplexing with 3'UTRs via Alu elements

lncRNAs transactivate Staufen1-mediated mRNA decay by duplexing with 3'UTRs via Alu elements

Staufen1 (STAU1)-mediated mRNA decay (SMD) degrades translationally active mRNAs that bind the double-stranded (ds)RNA binding protein STAU1 within their 3'-untranslated regions (3'UTRs)1,2. Earlier studies defined the STAU1 binding site (SBS) within ADP ribosylation factor 1 (ARF1) mRNA a...

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Bibliographic Details
Main Authors: Gong, Chenguang, Maquat, Lynne E.
Format: Online
Language:English
Published: 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3073508/

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