Enzymatic Blockade of the Ubiquitin-Proteasome Pathway

A viral ubiquitin-specific protease domain blocks cellular protein turnover by preemptive removal of ubiquitin chains and establishes an essential role for deubiquitylation in the removal of unfolded proteins from the endoplasmic reticulum.

Bibliographic Details
Main Authors: Ernst, Robert, Claessen, Jasper H. L., Mueller, Britta, Sanyal, Sumana, Spooner, Eric, van der Veen, Annemarthe G., Kirak, Oktay, Schlieker, Christian D., Weihofen, Wilhelm A., Ploegh, Hidde L.
Format: Online
Language:English
Published: Public Library of Science 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3066133/