Unfolded protein response in cancer: the Physician's perspective
The unfolded protein response (UPR) is a cascade of intracellular stress signaling events in response to an accumulation of unfolded or misfolded proteins in the lumen of the endoplasmic reticulum (ER). Cancer cells are often exposed to hypoxia, nutrient starvation, oxidative stress and other metabo...
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BioMed Central
2011
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3060154/ |
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pubmed-30601542011-03-18 Unfolded protein response in cancer: the Physician's perspective Li, Xuemei Zhang, Kezhong Li, Zihai Review The unfolded protein response (UPR) is a cascade of intracellular stress signaling events in response to an accumulation of unfolded or misfolded proteins in the lumen of the endoplasmic reticulum (ER). Cancer cells are often exposed to hypoxia, nutrient starvation, oxidative stress and other metabolic dysregulation that cause ER stress and activation of the UPR. Depending on the duration and degree of ER stress, the UPR can provide either survival signals by activating adaptive and antiapoptotic pathways, or death signals by inducing cell death programs. Sustained induction or repression of UPR pharmacologically may thus have beneficial and therapeutic effects against cancer. In this review, we discuss the basic mechanisms of UPR and highlight the importance of UPR in cancer biology. We also update the UPR-targeted cancer therapeutics currently in clinical trials. BioMed Central 2011-02-23 /pmc/articles/PMC3060154/ /pubmed/21345215 http://dx.doi.org/10.1186/1756-8722-4-8 Text en Copyright ©2011 Li et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Li, Xuemei Zhang, Kezhong Li, Zihai |
| spellingShingle |
Li, Xuemei Zhang, Kezhong Li, Zihai Unfolded protein response in cancer: the Physician's perspective |
| author_facet |
Li, Xuemei Zhang, Kezhong Li, Zihai |
| author_sort |
Li, Xuemei |
| title |
Unfolded protein response in cancer: the Physician's perspective |
| title_short |
Unfolded protein response in cancer: the Physician's perspective |
| title_full |
Unfolded protein response in cancer: the Physician's perspective |
| title_fullStr |
Unfolded protein response in cancer: the Physician's perspective |
| title_full_unstemmed |
Unfolded protein response in cancer: the Physician's perspective |
| title_sort |
unfolded protein response in cancer: the physician's perspective |
| description |
The unfolded protein response (UPR) is a cascade of intracellular stress signaling events in response to an accumulation of unfolded or misfolded proteins in the lumen of the endoplasmic reticulum (ER). Cancer cells are often exposed to hypoxia, nutrient starvation, oxidative stress and other metabolic dysregulation that cause ER stress and activation of the UPR. Depending on the duration and degree of ER stress, the UPR can provide either survival signals by activating adaptive and antiapoptotic pathways, or death signals by inducing cell death programs. Sustained induction or repression of UPR pharmacologically may thus have beneficial and therapeutic effects against cancer. In this review, we discuss the basic mechanisms of UPR and highlight the importance of UPR in cancer biology. We also update the UPR-targeted cancer therapeutics currently in clinical trials. |
| publisher |
BioMed Central |
| publishDate |
2011 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3060154/ |
| _version_ |
1611446071336108032 |