Gene–environment interactions in Leber hereditary optic neuropathy

Gene–environment interactions in Leber hereditary optic neuropathy

Leber hereditary optic neuropathy (LHON) is a genetic disorder primarily due to mutations of mitochondrial DNA (mtDNA). Environmental factors are thought to precipitate the visual failure and explain the marked incomplete penetrance of LHON, but previous small studies have failed to confirm this to...

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Bibliographic Details
Main Authors: Kirkman, Matthew Anthony, Yu-Wai-Man, Patrick, Korsten, Alex, Leonhardt, Miriam, Dimitriadis, Konstantin, De Coo, Ireneaus F., Klopstock, Thomas, Chinnery, Patrick Francis
Format: Online
Language:English
Published: Oxford University Press 2009
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2732267/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2732267/

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