Dissection of the Transformation of Primary Human Hematopoietic Cells by the Oncogene NUP98-HOXA9
NUP98-HOXA9 is the prototype of a group of oncoproteins associated with acute myeloid leukemia. It consists of an N-terminal portion of NUP98 fused to the homeodomain of HOXA9 and is believed to act as an aberrant transcription factor that binds DNA through the homeodomain. Here we show that NUP98-H...
| Main Authors: | , , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Public Library of Science
2009
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2725295/ |