Expression of Leukemia-Associated Nup98 Fusion Proteins Generates an Aberrant Nuclear Envelope Phenotype

Expression of Leukemia-Associated Nup98 Fusion Proteins Generates an Aberrant Nuclear Envelope Phenotype

Chromosomal translocations involving the nucleoporin NUP98 have been described in several hematopoietic malignancies, in particular acute myeloid leukemia (AML). In the resulting chimeric proteins, Nup98's N-terminal region is fused to the C-terminal region of about 30 different partners, inclu...

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Main Authors: Fahrenkrog, Birthe, Martinelli, Valérie, Nilles, Nadine, Fruhmann, Gernot, Chatel, Guillaume, Juge, Sabine, Sauder, Ursula, Di Giacomo, Danika, Mecucci, Cristina, Schwaller, Jürg
Format: Online
Language:English
Published: Public Library of Science 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4816316/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4816316/

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