Adenosine Kinase of T. b. rhodesiense Identified as the Putative Target of 4-[5-(4-phenoxyphenyl)-2H-pyrazol-3-yl]morpholine Using Chemical Proteomics

Adenosine Kinase of T. b. rhodesiense Identified as the Putative Target of 4-[5-(4-phenoxyphenyl)-2H-pyrazol-3-yl]morpholine Using Chemical Proteomics

Human African trypanosomiasis (HAT), a devastating and fatal parasitic disease endemic in sub-Saharan Africa, urgently needs novel targets and efficacious chemotherapeutic agents. Recently, we discovered that 4-[5-(4-phenoxyphenyl)-2H-pyrazol-3-yl]morpholine exhibits specific antitrypanosomal activi...

Full description

Bibliographic Details
Main Authors: Kuettel, Sabine, Mosimann, Marc, Mäser, Pascal, Kaiser, Marcel, Brun, Reto, Scapozza, Leonardo, Perozzo, Remo
Format: Online
Language:English
Published: Public Library of Science 2009
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2724708/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2724708/

Similar Items