F-Box Protein FBXO31 Mediates Cyclin D1 Degradation to Induce G1 Arrest Following DNA Damage
In response to DNA damage eukaryotic cells initiate a complex signalling pathway, termed the DNA damage response (DDR), which coordinates cell cycle arrest with DNA repair. Studies have shown that oncogene-induced senescence, which provides a barrier to tumour development, involves activation of the...
| Main Authors: | , , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
2009
|
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2722223/ |