The Parkinson’s disease genes Fbxo7 and Parkin interact to mediate mitophagy

The Parkinson’s disease genes Fbxo7 and Parkin interact to mediate mitophagy

Compelling evidence indicates that two autosomal recessive Parkinson’s disease genes, PINK1 (PARK6) and Parkin (PARK2), co-operate to mediate the autophagic clearance of damaged mitochondria (mitophagy). Mutations in the F-box domain containing protein Fbxo7 (PARK15) also cause early onset autosomal...

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Bibliographic Details
Main Authors: Burchell, Victoria S, Nelson, David E, Sanchez-Martinez, Alvaro, Delgado-Camprubi, Marta, Ivatt, Rachael M, Pogson, Joe H, Randle, Suzanne J, Wray, Selina, Lewis, Patrick A, Houlden, Henry, Abramov, Andrey Y, Hardy, John, Wood, Nicholas W, Whitworth, Alexander J, Laman, Heike, Plun-Favreau, Helene
Format: Online
Language:English
Published: 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3827746/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3827746/

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