Deficient activation by a human cell strain leads to mitomycin resistance under aerobic but not hypoxic conditions.
Two non-transformed human skin fibroblast strains, GM38 and 3437T, were found to be more sensitive to the bioreductive alkylating agents mitomycin C (MMC) and porfiromycin (PM) under hypoxic compared to aerobic conditions. One of these strains, 3437T, was 6-7 times more resistant to these agents und...
| Main Authors: | , , |
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| Format: | Online |
| Language: | English |
| Published: |
Nature Publishing Group
1989
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2247063/ |