Synthesis and Biological Analysis of Thiotetra(ethylene glycol) monomethyl Ether-Functionalized Porphyrazines: Cellular Uptake and Toxicity Studies

The porphyrazines (pzs), a class of porphyrin analogues, are being investigated for their potential use as tumor imaging/therapeutic agents. We here examine six peripherally-functionalized M[pz(AnB4-n)] pzs with n=4, 3, or 2 (in a trans conformation) and M = H2 or Zn, where A is an [S((CH2)2O)4Me]2...

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Bibliographic Details
Main Authors: Lee, Sangwan, Vesper, Benjamin J., Zong, Hong, Hammer, Neal D., Elseth, Kim M., Barrett, Anthony G. M., Hoffman, Brian M., Radosevich, James A.
Format: Online
Language:English
Published: Hindawi Publishing Corporation 2008
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2225588/