Tumor cells convert immature myeloid dendritic cells into TGF-β–secreting cells inducing CD4+CD25+ regulatory T cell proliferation

Tumor cells convert immature myeloid dendritic cells into TGF-β–secreting cells inducing CD4+CD25+ regulatory T cell proliferation

The mechanisms through which regulatory T cells accumulate in lymphoid organs of tumor-bearing hosts remain elusive. Our experiments indicate that the accumulation of CD4+CD25+ regulatory T cells (T reg cells) expressing FoxP3 and exhibiting immunosuppressive function originates from the proliferati...

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Bibliographic Details
Main Authors: Ghiringhelli, François, Puig, Pierre E., Roux, Stephan, Parcellier, Arnaud, Schmitt, Elise, Solary, Eric, Kroemer, Guido, Martin, François, Chauffert, Bruno, Zitvogel, Laurence
Format: Online
Language:English
Published: The Rockefeller University Press 2005
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213166/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213166/

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