The Innate Mononuclear Phagocyte Network Depletes B Lymphocytes through Fc Receptor–dependent Mechanisms during Anti-CD20 Antibody Immunotherapy

The Innate Mononuclear Phagocyte Network Depletes B Lymphocytes through Fc Receptor–dependent Mechanisms during Anti-CD20 Antibody Immunotherapy

Anti-CD20 antibody immunotherapy effectively treats non-Hodgkin's lymphoma and autoimmune disease. However, the cellular and molecular pathways for B cell depletion remain undefined because human mechanistic studies are limited. Proposed mechanisms include antibody-, effector cell–, and complem...

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Bibliographic Details
Main Authors: Uchida, Junji, Hamaguchi, Yasuhito, Oliver, Julie A., Ravetch, Jeffrey V., Poe, Jonathan C., Haas, Karen M., Tedder, Thomas F.
Format: Online
Language:English
Published: The Rockefeller University Press 2004
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212805/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212805/

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