Acidic Sphingomyelinase (ASM) Is Necessary for Fas-induced GD3 Ganglioside Accumulation and Efficient Apoptosis of Lymphoid Cells
Ceramides deriving from sphingomyelin hydrolysis are important mediators of apoptotic signals originating from Fas (APO-1/CD95). However, definitive evidence for the role played by individual sphingomyelinases is still lacking. We have analyzed lymphoblastoid cell lines derived from patients affecte...
| Main Authors: | , , , |
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| Format: | Online |
| Language: | English |
| Published: |
The Rockefeller University Press
1998
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212183/ |