PD-1 Inhibits Antiviral Immunity at the Effector Phase in the Liver

Unlike naive T cells, effector T cells can be activated by either T cell receptor signal or costimulatory signal alone and therefore the absence of costimulatory molecules on tissue cells cannot explain the tolerance mechanism at the effector phase. Here we report that PD-L1, the ligand for the immu...

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Bibliographic Details
Main Authors: Iwai, Yoshiko, Terawaki, Seigo, Ikegawa, Masaya, Okazaki, Taku, Honjo, Tasuku
Format: Online
Language:English
Published: The Rockefeller University Press 2003
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2196084/