Irradiation-Mediated Rescue of T Cell–Specific V(D)j Recombination and Thymocyte Differentiation in Severe Combined Immunodeficient Mice by Bone Marrow Cells

Irradiation-Mediated Rescue of T Cell–Specific V(D)j Recombination and Thymocyte Differentiation in Severe Combined Immunodeficient Mice by Bone Marrow Cells

In SCID (severe combined immunodeficient) mice, proper assembly of immunoglobulin and T cell receptor (TCR) genes is blocked by defective V(D)J recombination so that B and T lymphocyte differentiation is arrested at an early precursor stage. Treating the mice with gamma irradiation rescues V(D)J rea...

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Bibliographic Details
Main Authors:	Wang, Chiyu, Bogue, Molly A., Levitt, Jonathan M., Roth, David B.
Format:	Online
Language:	English
Published:	The Rockefeller University Press 1999
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2195679/

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