Use of V(D)J recombination excision circles to identify T- and B-cell defects and to monitor the treatment in primary and acquired immunodeficiencies

Use of V(D)J recombination excision circles to identify T- and B-cell defects and to monitor the treatment in primary and acquired immunodeficiencies

T-cell receptor excision circles (TRECs) and kappa-deleting recombination excision circles (KRECs) are circular DNA segments generated in T and B cells during their maturation in the thymus and bone marrow. These circularized DNA elements persist in the cells, are unable to replicate, and are dilute...

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Bibliographic Details
Main Authors: Serana, Federico, Chiarini, Marco, Zanotti, Cinzia, Sottini, Alessandra, Bertoli, Diego, Bosio, Andrea, Caimi, Luigi, Imberti, Luisa
Format: Online
Language:English
Published: BioMed Central 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3666889/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3666889/

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