Differential Requirement for LAT and SLP-76 in GPVI versus T Cell Receptor Signaling

Differential Requirement for LAT and SLP-76 in GPVI versus T Cell Receptor Signaling

Mice deficient in the adaptor Src homology 2 domain-containing leukocyte phosphoprotein of 76 kD (SLP-76) exhibit a bleeding disorder and lack T cells. Linker for activation of T cells (LAT)-deficient mice exhibit a similar T cell phenotype, but show no signs of hemorrhage. Both SLP-76 and LAT are i...

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Bibliographic Details
Main Authors: Judd, Barbi A., Myung, Peggy S., Obergfell, Achim, Myers, Erin E., Cheng, Alec M., Watson, Stephen P., Pear, Warren S., Allman, David, Shattil, Sanford J., Koretzky, Gary A.
Format: Online
Language:English
Published: The Rockefeller University Press 2002
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193740/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193740/

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